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ENZYME entry: EC 1.14.11.68

Accepted Name
[Histone H3]-trimethyl-L-lysine(27) demethylase.
Reaction catalysed
A [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(27) + 2 2-oxoglutarate + 2 O(2) <=> a [histone H3]-N(6)-methyl-L-lysine(27) + 2 succinate + 2 formaldehyde + 2 CO(2)
Comment(s)
  • Requires iron(II).
  • This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 27 of histone H3 (H3K27).
  • The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde.
  • They can act on tri- and di-methylated forms, but have no activity with the mono-methylated form.
Cross-references
BRENDA1.14.11.68
EC2PDB1.14.11.68
ExplorEnz1.14.11.68
PRIAM enzyme-specific profiles1.14.11.68
KEGG Ligand Database for Enzyme Nomenclature1.14.11.68
IUBMB Enzyme Nomenclature1.14.11.68
IntEnz1.14.11.68
MEDLINEFind literature relating to 1.14.11.68
MetaCyc1.14.11.68
Rhea expert-curated reactions1.14.11.68
UniProtKB/Swiss-Prot
O15550, KDM6A_HUMAN;  O70546, KDM6A_MOUSE;  O15054, KDM6B_HUMAN;  
Q5NCY0, KDM6B_MOUSE;  O14607, UTY_HUMAN;  P79457, UTY_MOUSE;  
Q6B4Z3, UTY_PANTR;  

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