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ENZYME

ENZYME entry: EC 1.14.11.68

PURL: https://purl.expasy.org/enzyme/EC/1.14.11.68
Accepted Name
[histone H3]-trimethyl-L-lysine(27) demethylase
Reaction catalysed
N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(27)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2
Comment(s)
  • Requires iron(II).
  • This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 27 of histone H3 (H3K27).
  • The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde.
  • They can act on tri- and di-methylated forms, but have no activity with the mono-methylated form.
Cross-references
BRENDA1.14.11.68
EC2PDB1.14.11.68
ExplorEnz1.14.11.68
KEGG Ligand Database for Enzyme Nomenclature1.14.11.68
IUBMB Enzyme Nomenclature1.14.11.68
MEDLINEFind literature relating to 1.14.11.68
MetaCyc1.14.11.68
Rhea expert-curated reactions1.14.11.68
UniProtKB/Swiss-Prot
Q5N712, JM705_ORYSJQ8RWR1, JMJ30_ARATHQ0WVR4, JMJ32_ARATH
O15550, KDM6A_HUMANO70546, KDM6A_MOUSEO15054, KDM6B_HUMAN
Q5NCY0, KDM6B_MOUSEO14607, UTY_HUMANP79457, UTY_MOUSE
Q6B4Z3, UTY_PANTR

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