ENZYME entry: EC 188.8.131.52
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|[Protein]-L-arginine + 2-oxoglutarate + O(2) <=> [protein]-(3R)-3-hydroxy-L-arginine + succinate + CO(2)|
- The enzyme, characterized from humans, catalyzes the stereoselective
formation of the (2S,3R)-hydroxy-L-arginine stereoisomer.
- So far the enzyme has been shown to act on two substrates - the 40S
ribosomal protein S6 (RPS6), which is hydroxylated at R137, and, at a
lower activity, RCCD1, a protein involved in chromatin stability,
which is hydroxylated at R141.
- Even though the same stereoisomer is produced by the bacterial
EC 184.108.40.206, the two enzymes do not exhibit any cross-reactivity on
their respective ribosomal protein substrates.
|PRIAM enzyme-specific profiles||220.127.116.11|
|KEGG Ligand Database for Enzyme Nomenclature||18.104.22.168|
|IUBMB Enzyme Nomenclature||22.214.171.124|
|MEDLINE||Find literature relating to 126.96.36.199|
|Rhea expert-curated reactions||188.8.131.52|
entries corresponding to 1.14.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-