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ENZYME entry: EC 1.14.11.73

Accepted Name
[Protein]-arginine 3-hydroxylase.
Reaction catalysed
[Protein]-L-arginine + 2-oxoglutarate + O(2) <=> [protein]-(3R)-3-hydroxy-L-arginine + succinate + CO(2)
Comment(s)
  • The enzyme, characterized from humans, catalyzes the stereoselective formation of the (2S,3R)-hydroxy-L-arginine stereoisomer.
  • So far the enzyme has been shown to act on two substrates - the 40S ribosomal protein S6 (RPS6), which is hydroxylated at R137, and, at a lower activity, RCCD1, a protein involved in chromatin stability, which is hydroxylated at R141.
  • Even though the same stereoisomer is produced by the bacterial EC 1.14.11.47, the two enzymes do not exhibit any cross-reactivity on their respective ribosomal protein substrates.
Cross-references
BRENDA1.14.11.73
EC2PDB1.14.11.73
ExplorEnz1.14.11.73
PRIAM enzyme-specific profiles1.14.11.73
KEGG Ligand Database for Enzyme Nomenclature1.14.11.73
IUBMB Enzyme Nomenclature1.14.11.73
IntEnz1.14.11.73
MEDLINEFind literature relating to 1.14.11.73
MetaCyc1.14.11.73
Rhea expert-curated reactions1.14.11.73
UniProtKB/Swiss-Prot
Q1JP61, KDM8_BOVIN;  Q8N371, KDM8_HUMAN;  Q9CXT6, KDM8_MOUSE;  
Q497B8, KDM8_RAT;  

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