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ENZYME entry: EC 1.14.11.9

Accepted Name
Flavanone 3-dioxygenase.
Alternative Name(s)
(2S)-flavanone 3-hydroxylase.
Flavanone 3-beta-hydroxylase.
Flavanone 3-hydroxylase.
Flavanone synthase I.
Naringenin 3-dioxygenase.
Naringenin 3-hydroxylase.
Reaction catalysed
A (2S)-flavan-4-one + 2-oxoglutarate + O(2) <=> a (2R,3R)-dihydroflavonol + succinate + CO(2)
Cofactor(s)
Fe(2+); L-ascorbate.
Comment(s)
  • This plant enzyme catalyzes an early step in the flavonoid biosynthesis pathway, leading to the production of flavanols and anthocyanins.
  • Substrates include (2S)-naringenin, (2S)-eriodictyol, (2S)- dihydrotricetin and (2S)-pinocembrin.
  • Some enzymes are bifuctional and also catalyze EC 1.14.20.6.
Cross-references
PROSITEPDOC51471
BRENDA1.14.11.9
EC2PDB1.14.11.9
ExplorEnz1.14.11.9
PRIAM enzyme-specific profiles1.14.11.9
KEGG Ligand Database for Enzyme Nomenclature1.14.11.9
IUBMB Enzyme Nomenclature1.14.11.9
IntEnz1.14.11.9
MEDLINEFind literature relating to 1.14.11.9
MetaCyc1.14.11.9
UniProtKB/Swiss-Prot
A0A4D6Q9B0, FL3H1_CROXC;  Q7XM21, FL3H1_ORYSJ;  A0A4D6Q4T7, FL3H2_CROXC;  
Q8W2X5, FL3H2_ORYSJ;  Q7XR84, FL3H3_ORYSJ;  Q9S818, FL3H_ARATH;  
Q05963, FL3H_CALCH;  Q05964, FL3H_DIACA;  P28038, FL3H_HORVU;  
Q06942, FL3H_MALDO;  Q05965, FL3H_MATIN;  Q7XZQ7, FL3H_PETCR;  
Q07353, FL3H_PETHY;  P41090, FL3H_VITVI;  Q96330, FLS1_ARATH;  
Q9ZWQ9, FLS_CITUN;  Q9M547, FLS_EUSER;  Q9XHG2, FLS_MALDO;  
O04395, FLS_MATIN;  Q7XZQ6, FLS_PETCR;  Q07512, FLS_PETHY;  
Q41452, FLS_SOLTU;  

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