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ENZYME

ENZYME entry: EC 1.14.11.9

PURL: https://purl.expasy.org/enzyme/EC/1.14.11.9
Accepted Name
flavanone 3-dioxygenase
Alternative Name(s)
(2S)-flavanone 3-hydroxylase
flavanone 3beta-hydroxylase
flavanone 3-hydroxylase
flavanone synthase I
naringenin 3-dioxygenase
naringenin 3-hydroxylase
Reaction catalysed
a (2S)-flavan-4-one + 2-oxoglutarate + O2 = a (2R,3R)-dihydroflavonol + succinate + CO2
Comment(s)
  • This plant enzyme catalyzes an early step in the flavonoid biosynthesis pathway, leading to the production of flavanols and anthocyanins.
  • Substrates include (2S)-naringenin, (2S)-eriodictyol, (2S)- dihydrotricetin and (2S)-pinocembrin.
  • Some enzymes are bifuctional and also catalyze EC 1.14.20.6.
Cross-references
BRENDA1.14.11.9
EC2PDB1.14.11.9
ExplorEnz1.14.11.9
KEGG Ligand Database for Enzyme Nomenclature1.14.11.9
IUBMB Enzyme Nomenclature1.14.11.9
MEDLINEFind literature relating to 1.14.11.9
MetaCyc1.14.11.9
Rhea expert-curated reactions1.14.11.9
UniProtKB/Swiss-Prot
A0A4D6Q9B0, FL3H1_CROXCQ7XM21, FL3H1_ORYSJA0A4D6Q4T7, FL3H2_CROXC
Q8W2X5, FL3H2_ORYSJQ7XR84, FL3H3_ORYSJQ9S818, FL3H_ARATH
Q05963, FL3H_CALCHQ05964, FL3H_DIACAP28038, FL3H_HORVU
Q06942, FL3H_MALDOQ05965, FL3H_MATINQ7XZQ7, FL3H_PETCR
Q07353, FL3H_PETHYP41090, FL3H_VITVIQ96330, FLS1_ARATH
Q9ZWQ9, FLS_CITUNQ9M547, FLS_EUSERQ9XHG2, FLS_MALDO
O04395, FLS_MATINQ7XZQ6, FLS_PETCRQ07512, FLS_PETHY
Q41452, FLS_SOLTU

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