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ENZYME entry: EC 1.14.11.n2

Accepted Name
Methylcytosine dioxygenase.
Reaction catalysed
DNA 5-methylcytosine + 2-oxoglutarate + O(2) <=> DNA 5-hydroxymethylcytosine + succinate + CO(2)
Cofactor(s)
Fe(2+).
Comment(s)
  • Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC).
  • Might initiate a process leading to cytosine demethylation through deamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system.
  • Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation.
Cross-references
UniProtKB/Swiss-Prot
Q8NFU7, TET1_HUMAN;  Q3URK3, TET1_MOUSE;  D2W6T1, TET1_NAEGR;  
Q6N021, TET2_HUMAN;  Q4JK59, TET2_MOUSE;  A0A1L8GSA2, TET3A_XENLA;  
K9JHZ4, TET3B_XENLA;  O43151, TET3_HUMAN;  Q8BG87, TET3_MOUSE;  
A0JP82, TET3_XENTR;  

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