ENZYME entry: EC 1.14.11.n2
| Accepted Name |
|---|
| Methylcytosine dioxygenase.
|
| Reaction catalysed |
|---|
| DNA 5-methylcytosine + 2-oxoglutarate + O(2) <=> DNA 5-hydroxymethylcytosine + succinate + CO(2) |
| Cofactor(s) |
|---|
| Fe(2+).
|
| Comment(s) |
|---|
- Dioxygenase that catalyzes the conversion of the modified genomic
base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC).
- Might initiate a process leading to cytosine demethylation through
deamination into 5-hydroxymethyluracil (5hmU) and subsequent
replacement by unmethylated cytosine by the base excision repair
system.
- Methylation at the C5 position of cytosine bases is an epigenetic
modification of the mammalian genome which plays an important role in
transcriptional regulation.
|
| Cross-references |
|---|
| UniProtKB/Swiss-Prot |
| Q8NFU7, TET1_HUMAN; | Q3URK3, TET1_MOUSE; | D2W6T1, TET1_NAEGR; |
| Q6N021, TET2_HUMAN; | Q4JK59, TET2_MOUSE; | A0A1L8GSA2, TET3A_XENLA; |
| K9JHZ4, TET3B_XENLA; | O43151, TET3_HUMAN; | Q8BG87, TET3_MOUSE; |
| A0JP82, TET3_XENTR; |
|
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UniProtKB/Swiss-Prot entries corresponding to 1.14.11.-
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