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ENZYME

ENZYME entry: EC 1.14.11.80

PURL: https://purl.expasy.org/enzyme/EC/1.14.11.80
Accepted Name
methylcytosine dioxygenase
Reaction catalysed
  • a 5-methyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + succinate + CO2
  • a 5-hydroxymethyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-formyl-2'-deoxycytidine in DNA + succinate + CO2 + H2O
  • a 5-formyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + succinate + CO2 + H(+)
Comment(s)
  • The TET proteins mediate iterative oxidation of 5-methylcytosine in DNA (5mc) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC).
  • 5fC and 5caC are recognized by EC 3.2.2.29, which excises them, leaving an apyrimidinic site.
  • Coupled with the base excision repair (BER) pathway, these activities result in a cytosine demethylation pathway.
  • Formerly EC 1.14.11.n2.
Cross-references
BRENDA1.14.11.80
EC2PDB1.14.11.80
ExplorEnz1.14.11.80
KEGG Ligand Database for Enzyme Nomenclature1.14.11.80
IUBMB Enzyme Nomenclature1.14.11.80
MEDLINEFind literature relating to 1.14.11.80
MetaCyc1.14.11.80
Rhea expert-curated reactions1.14.11.80
UniProtKB/Swiss-Prot
Q8NFU7, TET1_HUMANQ3URK3, TET1_MOUSED2W6T1, TET1_NAEGR
Q6N021, TET2_HUMANQ4JK59, TET2_MOUSEA0A1L8GSA2, TET3A_XENLA
K9JHZ4, TET3B_XENLAO43151, TET3_HUMANQ8BG87, TET3_MOUSE
A0JP82, TET3_XENTRM9NEY8, TET_DROME

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