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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
2,4-dinitrotoluene dioxygenase.
Reaction catalysed
2,4-dinitrotoluene + NADH + O(2) <=> 4-methyl-5-nitrocatechol + nitrite + NAD(+)
  • This enzyme, characterized from the bacterium Burkholderia sp. strain DNT, is a member of the naphthalene family of bacterial Rieske non- heme iron dioxygenases.
  • It comprises a multicomponent system, containing a Rieske [2Fe-2S] ferredoxin, an NADH-dependent flavoprotein reductase (EC, and an alpha-3-beta-3 oxygenase.
  • The enzyme forms a cis-dihydroxylated product that spontaneously rearranges to form a catechol with accompanying release of nitrite.
  • It does not act on nitrobenzene.
  • Cf. EC
PRIAM enzyme-specific profiles1.14.12.24
KEGG Ligand Database for Enzyme Nomenclature1.14.12.24
IUBMB Enzyme Nomenclature1.14.12.24
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