ENZYME entry: EC 1.14.13.111
Accepted Name |
Methanesulfonate monooxygenase (NADH).
|
Alternative Name(s) |
Mesylate monooxygenase. |
Methanesulfonic acid monooxygenase. |
MSA monooxygenase. |
MSAMO. |
Reaction catalysed |
Methanesulfonate + NADH + O(2) <=> formaldehyde + NAD(+) + sulfite + H(2)O |
Cofactor(s) |
Flavoprotein; Iron-sulfur.
|
Comment(s) |
- Methanesulfonate is the simplest of the sulfonates and is a substrate
for the growth of certain methylotrophic microorganisms.
- Compared with EC 1.14.14.5, this enzyme has a restricted substrate
range that includes only the short-chain aliphatic sulfonates
(methanesulfonate to butanesulfonate) and excludes all larger
molecules, such as arylsulfonates.
- The enzyme from the bacterium Methylosulfonomonas methylovora is a
multicomponent system comprising an hydroxylase, a reductase (MsmD)
and a ferredoxin (MsmC).
- The hydroxylase has both large (MsmA) and small (MsmB) subunits, with
each large subunit containing a Rieske-type [2Fe-2S] cluster.
- Formerly EC 1.14.14.6.
|
Cross-references |
BRENDA | 1.14.13.111 |
EC2PDB | 1.14.13.111 |
ExplorEnz | 1.14.13.111 |
PRIAM enzyme-specific profiles | 1.14.13.111 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.111 |
IUBMB Enzyme Nomenclature | 1.14.13.111 |
IntEnz | 1.14.13.111 |
MEDLINE | Find literature relating to 1.14.13.111 |
MetaCyc | 1.14.13.111 |
Rhea expert-curated reactions | 1.14.13.111 |
UniProtKB/Swiss-Prot |
|
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