Expasy logo

ENZYME

ENZYME entry: EC 1.14.13.179

PURL: https://purl.expasy.org/enzyme/EC/1.14.13.179
Accepted Name
methylxanthine N(3)-demethylase
Reaction catalysed
  • theobromine + NADH + O2 + H(+) = 7-methylxanthine + formaldehyde + NAD(+) + H2O
  • theobromine + NADPH + O2 + H(+) = 7-methylxanthine + formaldehyde + NADP(+) + H2O
  • 3-methylxanthine + NADH + O2 + H(+) = xanthine + formaldehyde + NAD(+) + H2O
  • 3-methylxanthine + NADPH + O2 + H(+) = xanthine + formaldehyde + NADP(+) + H2O
Comment(s)
  • The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.178, and has higher activity with NADH than with NADPH.
  • Also demethylates caffeine and theophylline with lower efficiency.
  • Forms part of the degradation pathway of methylxanthines.
Cross-references
BRENDA1.14.13.179
EC2PDB1.14.13.179
ExplorEnz1.14.13.179
KEGG Ligand Database for Enzyme Nomenclature1.14.13.179
IUBMB Enzyme Nomenclature1.14.13.179
MEDLINEFind literature relating to 1.14.13.179
MetaCyc1.14.13.179
Rhea expert-curated reactions1.14.13.179
UniProtKB/Swiss-Prot
H9N290, NDMB_PSEPU

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.13.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-