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ENZYME

ENZYME entry: EC 1.14.13.179

Accepted Name
methylxanthine N(3)-demethylase
Reaction catalysed
  • H(+) + NADH + O2 + theobromine = 7-methylxanthine + formaldehyde + H2O + NAD(+)
  • H(+) + NADPH + O2 + theobromine = 7-methylxanthine + formaldehyde + H2O + NADP(+)
  • 3-methylxanthine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + xanthine
  • 3-methylxanthine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + xanthine
Comment(s)
  • The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.178, and has higher activity with NADH than with NADPH.
  • Also demethylates caffeine and theophylline with lower efficiency.
  • Forms part of the degradation pathway of methylxanthines.
Cross-references
BRENDA1.14.13.179
EC2PDB1.14.13.179
ExplorEnz1.14.13.179
PRIAM enzyme-specific profiles1.14.13.179
KEGG Ligand Database for Enzyme Nomenclature1.14.13.179
IUBMB Enzyme Nomenclature1.14.13.179
IntEnz1.14.13.179
MEDLINEFind literature relating to 1.14.13.179
MetaCyc1.14.13.179
Rhea expert-curated reactions1.14.13.179
UniProtKB/Swiss-Prot
H9N290, NDMB_PSEPU

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