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ENZYME

ENZYME entry: EC 1.14.13.178

Accepted Name
methylxanthine N(1)-demethylase
Reaction catalysed
  • caffeine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + theobromine
  • caffeine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + theobromine
  • H(+) + NADPH + O2 + theophylline = 3-methylxanthine + formaldehyde + H2O + NADP(+)
  • H(+) + NADH + O2 + theophylline = 3-methylxanthine + formaldehyde + H2O + NAD(+)
  • 1,7-dimethylxanthine + H(+) + NADH + O2 = 7-methylxanthine + formaldehyde + H2O + NAD(+)
  • 1,7-dimethylxanthine + H(+) + NADPH + O2 = 7-methylxanthine + formaldehyde + H2O + NADP(+)
Comment(s)
  • The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.179, and has a 5-fold higher activity with NADH than with NADPH.
  • Also demethylates 1-methylxantine with lower efficiency.
  • Forms part of the degradation pathway of methylxanthines.
Cross-references
BRENDA1.14.13.178
EC2PDB1.14.13.178
ExplorEnz1.14.13.178
PRIAM enzyme-specific profiles1.14.13.178
KEGG Ligand Database for Enzyme Nomenclature1.14.13.178
IUBMB Enzyme Nomenclature1.14.13.178
IntEnz1.14.13.178
MEDLINEFind literature relating to 1.14.13.178
MetaCyc1.14.13.178
Rhea expert-curated reactions1.14.13.178
UniProtKB/Swiss-Prot
H9N289, NDMA_PSEPU

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