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ENZYME entry: EC 1.14.13.181
| Accepted Name |
|---|
| 13-deoxydaunorubicin hydroxylase.
|
| Reaction catalysed |
|---|
- 13-deoxydaunorubicin + H(+) + NADPH + O2 <=> 13-dihydrodaunorubicin + H2O + NADP(+)
- 13-dihydrodaunorubicin + H(+) + NADPH + O2 <=> daunorubicin + 2 H2O + NADP(+)
|
| Comment(s) |
|---|
| The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and
Streptomyces peucetius show broad substrate specificity for
structures based on an anthracycline aglycone, but have a strong
preference for 4-methoxy anthracycline intermediates
(13-deoxydaunorubicin and 13-dihydrodaunorubicin) over their
4-hydroxy analogs (13-deoxycarminomycin and 13-dihydrocarminomycin),
as well as a preference for substrates hydroxylated at the C-13
rather than the C-14 position.
|
| Cross-references |
|---|
| BRENDA | 1.14.13.181 |
| EC2PDB | 1.14.13.181 |
| ExplorEnz | 1.14.13.181 |
| PRIAM enzyme-specific profiles | 1.14.13.181 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.181 |
| IUBMB Enzyme Nomenclature | 1.14.13.181 |
| IntEnz | 1.14.13.181 |
| MEDLINE | Find literature relating to 1.14.13.181 |
| MetaCyc | 1.14.13.181 |
| Rhea expert-curated reactions | 1.14.13.181 |
| UniProtKB/Swiss-Prot |
|
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