ENZYME

ENZYME entry: EC 1.14.13.181

Accepted Name

13-deoxydaunorubicin hydroxylase.

Reaction catalysed

13-deoxydaunorubicin + NADPH + O(2) <=> 13-dihydrodaunorubicin + NADP(+) + H(2)O
13-dihydrodaunorubicin + NADPH + O(2) <=> daunorubicin + NADP(+) + 2 H(2)O

Comment(s)

The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius show broad substrate specificity for structures based on an anthracycline aglycone, but have a strong preference for 4-methoxy anthracycline intermediates (13-deoxydaunorubicin and 13-dihydrodaunorubicin) over their 4-hydroxy analogs (13-deoxycarminomycin and 13-dihydrocarminomycin), as well as a preference for substrates hydroxylated at the C-13 rather than the C-14 position.

Cross-references

BRENDA

1.14.13.181

EC2PDB

1.14.13.181

ExplorEnz

1.14.13.181

PRIAM enzyme-specific profiles

1.14.13.181

KEGG Ligand Database for Enzyme Nomenclature

1.14.13.181

IUBMB Enzyme Nomenclature