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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.13.195

Accepted Name
L-ornithine N(5)-monooxygenase (NADPH).
Alternative Name(s)
Ornithine hydroxylase.
Reaction catalysed
L-ornithine + NADPH + O(2) <=> N(5)-hydroxy-L-ornithine + NADP(+) + H(2)O
Cofactor(s)
FAD.
Comment(s)
  • The enzyme is involved in biosynthesis of N(5)-hydroxy-L-ornithine, N(5)-formyl-N(5)-hydroxy-L-ornithine or N(5)-acetyl-N(5)-hydroxy-L- ornithine.
  • These nonproteinogenic amino acids are building blocks of siderophores produced by some bacteria (e.g. Streptomyces coelicolor, Saccharopolyspora erythraea and Pseudomonas aeruginosa).
  • The enzyme is specific for NADPH.
  • Cf. EC 1.14.13.196.
Cross-references
BRENDA1.14.13.195
EC2PDB1.14.13.195
ExplorEnz1.14.13.195
PRIAM enzyme-specific profiles1.14.13.195
KEGG Ligand Database for Enzyme Nomenclature1.14.13.195
IUBMB Enzyme Nomenclature1.14.13.195
IntEnz1.14.13.195
MEDLINEFind literature relating to 1.14.13.195
MetaCyc1.14.13.195
UniProtKB/Swiss-Prot
O51940, PVDA_BURCE;  Q51548, PVDA_PSEAE;  

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