A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.14.13.196
| Accepted Name |
|---|
| L-ornithine N(5)-monooxygenase (NAD(P)H).
|
| Reaction catalysed |
|---|
| L-ornithine + NAD(P)H + O(2) <=> N(5)-hydroxy-L-ornithine + NAD(P)(+) + H(2)O |
| Cofactor(s) |
|---|
| FAD.
|
| Comment(s) |
|---|
- The enzyme from the pathogenic fungus Aspergillus fumigatus catalyzes
a step in the biosynthesis of the siderophores triacetylfusarinine
and desferriferricrocin, while the enzyme from the bacterium
Kutzneria sp. 744 is involved in the biosynthesis of piperazate,
a building block of the kutzneride family of antifungal antibiotics.
- Activity of the fungal enzyme is higher with NADPH, due to the fact
that following the reduction of the flavin, NADP(+) (but not NAD(+))
stabilizes the C4a-hydroperoxyflavin intermediate that oxidizes the
substrate.
- Cf. EC 1.14.13.195.
|
| Cross-references |
|---|
| BRENDA | 1.14.13.196 |
| EC2PDB | 1.14.13.196 |
| ExplorEnz | 1.14.13.196 |
| PRIAM enzyme-specific profiles | 1.14.13.196 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.196 |
| IUBMB Enzyme Nomenclature | 1.14.13.196 |
| IntEnz | 1.14.13.196 |
| MEDLINE | Find literature relating to 1.14.13.196 |
| MetaCyc | 1.14.13.196 |
| UniProtKB/Swiss-Prot |
| N4WYI1, SIDA2_COCH4; | B2KWI1, SIDA_AJECA; | D4AU57, SIDA_ARTBC; |
| E9QYP0, SIDA_ASPFU; | Q2TZB2, SIDA_ASPOR; | M2PP75, SIDA_CERS8; |
| G5EB76, SIDA_EMENI; | I1RN13, SIDA_GIBZE; | Q52UT0, SIDA_OMPOL; |
| Q9P7T0, SIDA_SCHPO; | P56584, SIDA_USTMA; |
|
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
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