Home  |  Contact

ENZYME entry: EC

Accepted Name
Tetracenomycin A2 monooxygenase-diooxygenase.
Reaction catalysed
Tetracenomycin A2 + 2 O(2) + 2 NAD(P)H <=> tetracenomycin C + 2 NAD(P)(+) + H(2)O
  • Isolated from the bacterium Streptomyces glaucescens.
  • The enzyme was also isolated from the bacterium Streptomyces olivaceus, where it acts on 8-demethyltetracenomycin A2 (tetracenomycin B2) as part of elloramycin biosynthesis.
  • The reaction involves a monooxygenase reaction which is followed by a dioxygenase reaction giving a gem-diol and an epoxide.
  • Water opens the epoxide giving two hydroxy groups.
  • The gem-diol eliminates water to give a ketone which is then reduced to a hydroxy group.
PRIAM enzyme-specific profiles1.14.13.200
KEGG Ligand Database for Enzyme Nomenclature1.14.13.200
IUBMB Enzyme Nomenclature1.14.13.200
MEDLINEFind literature relating to
Rhea expert-curated reactions1.14.13.200

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.13.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-