Home  |  Contact

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.13.200

Accepted Name
Tetracenomycin A2 monooxygenase-diooxygenase.
Reaction catalysed
Tetracenomycin A2 + 2 O(2) + 2 NAD(P)H <=> tetracenomycin C + 2 NAD(P)(+) + H(2)O
Comment(s)
  • Isolated from the bacterium Streptomyces glaucescens.
  • The enzyme was also isolated from the bacterium Streptomyces olivaceus, where it acts on 8-demethyltetracenomycin A2 (tetracenomycin B2) as part of elloramycin biosynthesis.
  • The reaction involves a monooxygenase reaction which is followed by a dioxygenase reaction giving a gem-diol and an epoxide.
  • Water opens the epoxide giving two hydroxy groups.
  • The gem-diol eliminates water to give a ketone which is then reduced to a hydroxy group.
Cross-references
BRENDA1.14.13.200
EC2PDB1.14.13.200
ExplorEnz1.14.13.200
PRIAM enzyme-specific profiles1.14.13.200
KEGG Ligand Database for Enzyme Nomenclature1.14.13.200
IUBMB Enzyme Nomenclature1.14.13.200
IntEnz1.14.13.200
MEDLINEFind literature relating to 1.14.13.200
MetaCyc1.14.13.200

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.13.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-