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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Tetracenomycin A2 monooxygenase-diooxygenase.
Reaction catalysed
Tetracenomycin A2 + 2 O(2) + 2 NAD(P)H <=> tetracenomycin C + 2 NAD(P)(+) + H(2)O
  • Isolated from the bacterium Streptomyces glaucescens.
  • The enzyme was also isolated from the bacterium Streptomyces olivaceus, where it acts on 8-demethyltetracenomycin A2 (tetracenomycin B2) as part of elloramycin biosynthesis.
  • The reaction involves a monooxygenase reaction which is followed by a dioxygenase reaction giving a gem-diol and an epoxide.
  • Water opens the epoxide giving two hydroxy groups.
  • The gem-diol eliminates water to give a ketone which is then reduced to a hydroxy group.
PRIAM enzyme-specific profiles1.14.13.200
KEGG Ligand Database for Enzyme Nomenclature1.14.13.200
IUBMB Enzyme Nomenclature1.14.13.200
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.13.-
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