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ENZYME entry: EC 1.14.13.200

Accepted Name
tetracenomycin A2 monooxygenase-diooxygenase.
Reaction catalysed
  • 2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 <=> H2O + 2 NADP(+) + tetracenomycin C
  • 2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 <=> H2O + 2 NAD(+) + tetracenomycin C
Comment(s)
  • Isolated from the bacterium Streptomyces glaucescens.
  • The enzyme was also isolated from the bacterium Streptomyces olivaceus, where it acts on 8-demethyltetracenomycin A2 (tetracenomycin B2) as part of elloramycin biosynthesis.
  • The reaction involves a monooxygenase reaction which is followed by a dioxygenase reaction giving a gem-diol and an epoxide.
  • Water opens the epoxide giving two hydroxy groups.
  • The gem-diol eliminates water to give a ketone which is then reduced to a hydroxy group.
Cross-references
BRENDA1.14.13.200
EC2PDB1.14.13.200
ExplorEnz1.14.13.200
PRIAM enzyme-specific profiles1.14.13.200
KEGG Ligand Database for Enzyme Nomenclature1.14.13.200
IUBMB Enzyme Nomenclature1.14.13.200
IntEnz1.14.13.200
MEDLINEFind literature relating to 1.14.13.200
MetaCyc1.14.13.200
Rhea expert-curated reactions1.14.13.200

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