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ENZYME

ENZYME entry: EC 1.14.13.211

Accepted Name
rifampicin monooxygenase
Alternative Name(s)
RIF-O
Reaction catalysed
  • NADPH + O2 + rifampicin = H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide
  • NADH + O2 + rifampicin = H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide
Comment(s)
  • The enzyme has been found in a variety of environmental bacteria, notably Rhodococcus, Nocardia, and Streptomyces.
  • It hydroxylates C-2 of rifampicin leading to the linearization of the molecule.
Cross-references
BRENDA1.14.13.211
EC2PDB1.14.13.211
ExplorEnz1.14.13.211
PRIAM enzyme-specific profiles1.14.13.211
KEGG Ligand Database for Enzyme Nomenclature1.14.13.211
IUBMB Enzyme Nomenclature1.14.13.211
IntEnz1.14.13.211
MEDLINEFind literature relating to 1.14.13.211
MetaCyc1.14.13.211
Rhea expert-curated reactions1.14.13.211
UniProtKB/Swiss-Prot
Q5YTV5, ROX_NOCFAP95598, ROX_RHOHAF2R776, ROX_STRVP

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