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ENZYME entry: EC 1.14.13.22

Accepted Name
Cyclohexanone monooxygenase.
Alternative Name(s)
Cyclohexanone 1,2-monooxygenase.
Cyclohexanone oxygenase.
Cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2- lactonizing).
Reaction catalysed
Cyclohexanone + NADPH + O(2) <=> hexano-6-lactone + NADP(+) + H(2)O
Cofactor(s)
FAD.
Comment(s)
  • In the catalytic mechanism of this enzyme, the nucleophilic species that attacks the carbonyl group is a peroxyflavin intermediate that is generated by reaction of the enzyme-bound flavin cofactor with NAD(P)H and oxygen.
  • This enzyme is able to catalyze a wide range of oxidative reactions, including enantioselective Baeyer-Villiger reactions, sulfoxidations, amine oxidations and epoxidations.
Cross-references
BRENDA1.14.13.22
EC2PDB1.14.13.22
ExplorEnz1.14.13.22
PRIAM enzyme-specific profiles1.14.13.22
KEGG Ligand Database for Enzyme Nomenclature1.14.13.22
IUBMB Enzyme Nomenclature1.14.13.22
IntEnz1.14.13.22
MEDLINEFind literature relating to 1.14.13.22
MetaCyc1.14.13.22
Rhea expert-curated reactions1.14.13.22
UniProtKB/Swiss-Prot
P12015, CHMO_ACISP

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