A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.14.13.22
| Accepted Name |
|---|
| Cyclohexanone monooxygenase.
|
| Alternative Name(s) |
|---|
| Cyclohexanone 1,2-monooxygenase. |
| Cyclohexanone oxygenase. |
| Cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-
lactonizing). |
| Reaction catalysed |
|---|
| Cyclohexanone + NADPH + O(2) <=> hexano-6-lactone + NADP(+) + H(2)O |
| Cofactor(s) |
|---|
| FAD.
|
| Comment(s) |
|---|
- In the catalytic mechanism of this enzyme, the nucleophilic species
that attacks the carbonyl group is a peroxyflavin intermediate that
is generated by reaction of the enzyme-bound flavin cofactor with
NAD(P)H and oxygen.
- This enzyme is able to catalyze a wide range of oxidative reactions,
including enantioselective Baeyer-Villiger reactions, sulfoxidations,
amine oxidations and epoxidations.
|
| Cross-references |
|---|
| BRENDA | 1.14.13.22 |
| EC2PDB | 1.14.13.22 |
| ExplorEnz | 1.14.13.22 |
| PRIAM enzyme-specific profiles | 1.14.13.22 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.22 |
| IUBMB Enzyme Nomenclature | 1.14.13.22 |
| IntEnz | 1.14.13.22 |
| MEDLINE | Find literature relating to 1.14.13.22 |
| MetaCyc | 1.14.13.22 |
| UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.14.13.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-