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ENZYME entry: EC 1.14.13.225

Accepted Name
F-actin monooxygenase.
Reaction catalysed
[F-actin]-L-methionine + NADPH + O(2) + H(+) <=> [F-actin]-L-methionine-(R)-S-oxide + NADP(+) + H(2)O
Comment(s)
  • The enzyme, characterized from the fruit fly Drosophila melanogaster, is a multi-domain oxidoreductase that acts as an F-actin disassembly factor.
  • The enzyme selectively reduces two L-Met residues of F-actin, causing fragmentation of the filaments and preventing repolymerization.
  • Free methionine is not a substrate.
  • The reaction is stereospecific and generates the (R)-sulfoxide.
Cross-references
BRENDA1.14.13.225
EC2PDB1.14.13.225
ExplorEnz1.14.13.225
PRIAM enzyme-specific profiles1.14.13.225
KEGG Ligand Database for Enzyme Nomenclature1.14.13.225
IUBMB Enzyme Nomenclature1.14.13.225
IntEnz1.14.13.225
MEDLINEFind literature relating to 1.14.13.225
MetaCyc1.14.13.225
Rhea expert-curated reactions1.14.13.225
UniProtKB/Swiss-Prot
F1RA39, MCA2B_DANRE;  F1QH17, MCA3A_DANRE;  F1QWK4, MCA3B_DANRE;  
F1MH07, MICA1_BOVIN;  E7F9T0, MICA1_DANRE;  Q8TDZ2, MICA1_HUMAN;  
Q8VDP3, MICA1_MOUSE;  D3ZBP4, MICA1_RAT;  F1MF74, MICA2_BOVIN;  
O94851, MICA2_HUMAN;  Q8BML1, MICA2_MOUSE;  D4A1F2, MICA2_RAT;  
F6QZ15, MICA2_XENTR;  G3MWR8, MICA3_BOVIN;  Q7RTP6, MICA3_HUMAN;  
Q8CJ19, MICA3_MOUSE;  Q86BA1, MICAL_DROME;  

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