A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.14.13.225
| Accepted Name |
|---|
| F-actin monooxygenase.
|
| Reaction catalysed |
|---|
| [F-actin]-L-methionine + NADPH + O(2) + H(+) <=> [F-actin]-L-methionine-(R)-S-oxide + NADP(+) + H(2)O |
| Comment(s) |
|---|
- The enzyme, characterized from the fruit fly Drosophila melanogaster,
is a multi-domain oxidoreductase that acts as an F-actin disassembly
factor.
- The enzyme selectively reduces two L-Met residues of F-actin, causing
fragmentation of the filaments and preventing repolymerization.
- Free methionine is not a substrate.
- The reaction is stereospecific and generates the (R)-sulfoxide.
|
| Cross-references |
|---|
| BRENDA | 1.14.13.225 |
| EC2PDB | 1.14.13.225 |
| ExplorEnz | 1.14.13.225 |
| PRIAM enzyme-specific profiles | 1.14.13.225 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.225 |
| IUBMB Enzyme Nomenclature | 1.14.13.225 |
| IntEnz | 1.14.13.225 |
| MEDLINE | Find literature relating to 1.14.13.225 |
| MetaCyc | 1.14.13.225 |
| UniProtKB/Swiss-Prot |
| F1RA39, MCA2B_DANRE; | F1QH17, MCA3A_DANRE; | F1QWK4, MCA3B_DANRE; |
| F1MH07, MICA1_BOVIN; | E7F9T0, MICA1_DANRE; | Q8TDZ2, MICA1_HUMAN; |
| Q8VDP3, MICA1_MOUSE; | D3ZBP4, MICA1_RAT; | F1MF74, MICA2_BOVIN; |
| O94851, MICA2_HUMAN; | Q8BML1, MICA2_MOUSE; | D4A1F2, MICA2_RAT; |
| F6QZ15, MICA2_XENTR; | G3MWR8, MICA3_BOVIN; | Q7RTP6, MICA3_HUMAN; |
| Q8CJ19, MICA3_MOUSE; | Q86BA1, MICAL_DROME; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.14.13.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
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