ENZYME entry: EC 1.14.13.225
Accepted Name |
F-actin monooxygenase.
|
Reaction catalysed |
[F-actin]-L-methionine + NADPH + O(2) + H(+) <=> [F-actin]-L-methionine-(R)-S-oxide + NADP(+) + H(2)O |
Comment(s) |
- The enzyme, characterized from the fruit fly Drosophila melanogaster,
is a multi-domain oxidoreductase that acts as an F-actin disassembly
factor.
- The enzyme selectively reduces two L-Met residues of F-actin, causing
fragmentation of the filaments and preventing repolymerization.
- Free methionine is not a substrate.
- The reaction is stereospecific and generates the (R)-sulfoxide.
|
Cross-references |
BRENDA | 1.14.13.225 |
EC2PDB | 1.14.13.225 |
ExplorEnz | 1.14.13.225 |
PRIAM enzyme-specific profiles | 1.14.13.225 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.225 |
IUBMB Enzyme Nomenclature | 1.14.13.225 |
IntEnz | 1.14.13.225 |
MEDLINE | Find literature relating to 1.14.13.225 |
MetaCyc | 1.14.13.225 |
Rhea expert-curated reactions | 1.14.13.225 |
UniProtKB/Swiss-Prot |
F1RA39, MCA2B_DANRE; | F1QH17, MCA3A_DANRE; | F1QWK4, MCA3B_DANRE; |
F1MH07, MICA1_BOVIN; | E7F9T0, MICA1_DANRE; | Q8TDZ2, MICA1_HUMAN; |
Q8VDP3, MICA1_MOUSE; | D3ZBP4, MICA1_RAT; | F1MF74, MICA2_BOVIN; |
O94851, MICA2_HUMAN; | Q8BML1, MICA2_MOUSE; | D4A1F2, MICA2_RAT; |
F6QZ15, MICA2_XENTR; | G3MWR8, MICA3_BOVIN; | Q7RTP6, MICA3_HUMAN; |
Q8CJ19, MICA3_MOUSE; | Q86BA1, MICAL_DROME; |
|
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