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ENZYME

ENZYME entry: EC 1.14.13.225

PURL: https://purl.expasy.org/enzyme/EC/1.14.13.225
Accepted Name
F-actin monooxygenase
Reaction catalysed
L-methionyl-[F-actin] + NADPH + O2 + H(+) = L-methionyl-(R)-S-oxide-[F-actin] + NADP(+) + H2O
Comment(s)
  • The enzyme, characterized from the fruit fly Drosophila melanogaster, is a multi-domain oxidoreductase that acts as an F-actin disassembly factor.
  • The enzyme selectively reduces two L-Met residues of F-actin, causing fragmentation of the filaments and preventing repolymerization.
  • Free methionine is not a substrate.
  • The reaction is stereospecific and generates the (R)-sulfoxide.
Cross-references
BRENDA1.14.13.225
EC2PDB1.14.13.225
ExplorEnz1.14.13.225
KEGG Ligand Database for Enzyme Nomenclature1.14.13.225
IUBMB Enzyme Nomenclature1.14.13.225
MEDLINEFind literature relating to 1.14.13.225
MetaCyc1.14.13.225
Rhea expert-curated reactions1.14.13.225
UniProtKB/Swiss-Prot
F1RA39, MCA2B_DANREF1QH17, MCA3A_DANREF1QWK4, MCA3B_DANRE
F1MH07, MICA1_BOVINE7F9T0, MICA1_DANREQ8TDZ2, MICA1_HUMAN
Q8VDP3, MICA1_MOUSED3ZBP4, MICA1_RATF1MF74, MICA2_BOVIN
O94851, MICA2_HUMANQ8BML1, MICA2_MOUSED4A1F2, MICA2_RAT
F6QZ15, MICA2_XENTRG3MWR8, MICA3_BOVINQ7RTP6, MICA3_HUMAN
Q8CJ19, MICA3_MOUSEQ86BA1, MICAL_DROME

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