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ENZYME entry: EC 1.14.13.231

Accepted Name
Tetracycline 11a-monooxygenase.
Reaction catalysed
Tetracycline + NADPH + O(2) <=> 11a-hydroxytetracycline + NADP(+) + H(2)O
Cofactor(s)
FAD.
Comment(s)
  • This bacterial enzyme confers resistance to all clinically relevant tetracyclines when expressed under aerobic conditions.
  • The hydroxylated products are very unstable and lead to intramolecular cyclization and non-enzymic breakdown to undefined products.
Cross-references
BRENDA1.14.13.231
EC2PDB1.14.13.231
ExplorEnz1.14.13.231
PRIAM enzyme-specific profiles1.14.13.231
KEGG Ligand Database for Enzyme Nomenclature1.14.13.231
IUBMB Enzyme Nomenclature1.14.13.231
IntEnz1.14.13.231
MEDLINEFind literature relating to 1.14.13.231
MetaCyc1.14.13.231
Rhea expert-curated reactions1.14.13.231
UniProtKB/Swiss-Prot
Q01911, TETX_BACFG;  Q93L51, TETX_BACT4;  B1MM05, TETX_MYCA9;  
Q06DK7, TETX_SPHSM;  

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