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ENZYME

ENZYME entry: EC 1.14.13.231

PURL: https://purl.expasy.org/enzyme/EC/1.14.13.231
Accepted Name
tetracycline 11a-monooxygenase
Reaction catalysed
tetracycline + NADPH + O2 + H(+) = 11a-hydroxytetracycline + NADP(+) + H2O
Comment(s)
  • This bacterial enzyme confers resistance to all clinically relevant tetracyclines when expressed under aerobic conditions.
  • The hydroxylated products are very unstable and lead to intramolecular cyclization and non-enzymic breakdown to undefined products.
Cross-references
BRENDA1.14.13.231
EC2PDB1.14.13.231
ExplorEnz1.14.13.231
KEGG Ligand Database for Enzyme Nomenclature1.14.13.231
IUBMB Enzyme Nomenclature1.14.13.231
MEDLINEFind literature relating to 1.14.13.231
MetaCyc1.14.13.231
Rhea expert-curated reactions1.14.13.231
UniProtKB/Swiss-Prot
Q01911, TETX_BACFGQ93L51, TETX_BACT4B1MM05, TETX_MYCA9
Q06DK7, TETX_SPHSM

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