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ENZYME entry: EC 1.14.13.232

Accepted Name
6-methylpretetramide 4-monooxygenase.
Reaction catalysed
6-methylpretetramide + NADPH + O(2) <=> 4-hydroxy-6-methylpretetramide + NADP(+) + H(2)O
Cofactor(s)
FAD.
Comment(s)
  • The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics.
  • That bacterium possesses two enzymes that can catalyze the reaction - OxyE is the main isozyme, while OxyL has a lower activity.
  • OxyL is bifunctional, and its main function is EC 1.14.13.233.
Cross-references
BRENDA1.14.13.232
EC2PDB1.14.13.232
ExplorEnz1.14.13.232
PRIAM enzyme-specific profiles1.14.13.232
KEGG Ligand Database for Enzyme Nomenclature1.14.13.232
IUBMB Enzyme Nomenclature1.14.13.232
IntEnz1.14.13.232
MEDLINEFind literature relating to 1.14.13.232
MetaCyc1.14.13.232
Rhea expert-curated reactions1.14.13.232
UniProtKB/Swiss-Prot
Q3S8R0, OXYE_STRRM;  Q3S8Q4, OXYL_STRRM;  

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