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ENZYME entry: EC 1.14.13.233

Accepted Name
4-hydroxy-6-methylpretetramide 12a-monooxygenase.
Reaction catalysed
4-hydroxy-6-methylpretetramide + NADPH + O(2) <=> 4-dedimethylamino-4-oxoanhydrotetracycline + NADP(+) + H(2)O
Cofactor(s)
FAD.
Comment(s)
  • The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics.
  • The enzyme is bifunctional, and can also catalyze EC 1.14.13.232.
Cross-references
BRENDA1.14.13.233
EC2PDB1.14.13.233
ExplorEnz1.14.13.233
PRIAM enzyme-specific profiles1.14.13.233
KEGG Ligand Database for Enzyme Nomenclature1.14.13.233
IUBMB Enzyme Nomenclature1.14.13.233
IntEnz1.14.13.233
MEDLINEFind literature relating to 1.14.13.233
MetaCyc1.14.13.233
UniProtKB/Swiss-Prot
Q3S8Q4, OXYL_STRRM

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