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ENZYME

ENZYME entry: EC 1.14.13.233

Accepted Name
4-hydroxy-6-methylpretetramide 12a-monooxygenase
Reaction catalysed
4-hydroxy-6-methylpretetramide + NADPH + O2 = 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)
Comment(s)
  • The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics.
  • The enzyme is bifunctional, and can also catalyze EC 1.14.13.232.
Cross-references
BRENDA1.14.13.233
EC2PDB1.14.13.233
ExplorEnz1.14.13.233
PRIAM enzyme-specific profiles1.14.13.233
KEGG Ligand Database for Enzyme Nomenclature1.14.13.233
IUBMB Enzyme Nomenclature1.14.13.233
IntEnz1.14.13.233
MEDLINEFind literature relating to 1.14.13.233
MetaCyc1.14.13.233
Rhea expert-curated reactions1.14.13.233
UniProtKB/Swiss-Prot
Q3S8Q4, OXYL_STRRM

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