ENZYME entry: EC 1.14.13.242
Accepted Name |
3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase.
|
Alternative Name(s) |
3-hydroxy-2-methylpyridinecarboxylate dioxygenase. |
methylhydroxypyridine carboxylate dioxygenase. |
methylhydroxypyridinecarboxylate oxidase. |
MHPCO. |
Reaction catalysed |
- 3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 <=> 2-(acetamidomethylene)succinate + NAD(+)
- 3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 <=> 2-(acetamidomethylene)succinate + NADP(+)
|
Comment(s) |
- The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and
Mesorhizobium loti, participates in the degradation of pyridoxine
(vitamin B6).
- Although the enzyme was initially thought to be a dioxygenase,
oxygen-tracer experiments have shown that it is a monooxygnase,
incorporating only one oxygen atom from molecular oxygen.
- The second oxygen atom that is incorporated into the product
originates from a water molecule, which is regenerated during the
reaction and thus does not show up in the reaction equation.
- Formerly EC 1.14.12.4.
|
Cross-references |
BRENDA | 1.14.13.242 |
EC2PDB | 1.14.13.242 |
ExplorEnz | 1.14.13.242 |
PRIAM enzyme-specific profiles | 1.14.13.242 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.242 |
IUBMB Enzyme Nomenclature | 1.14.13.242 |
IntEnz | 1.14.13.242 |
MEDLINE | Find literature relating to 1.14.13.242 |
MetaCyc | 1.14.13.242 |
Rhea expert-curated reactions | 1.14.13.242 |
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