ENZYME

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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.13.242

Accepted Name
3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase.
Alternative Name(s)
3-hydroxy-2-methylpyridinecarboxylate dioxygenase.
Methylhydroxypyridine carboxylate dioxygenase.
Methylhydroxypyridinecarboxylate oxidase.
MHPCO.
Reaction catalysed
3-hydroxy-2-methylpyridine-5-carboxylate + NAD(P)H + O(2) <=> 2-(acetamidomethylene)succinate + NAD(P)(+)
Cofactor(s)
FAD.
Comment(s)
The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and Mesorhizobium loti, participates in the degradation of pyridoxine (vitamin B(6)). Although the enzyme was initially thought to be a dioxygenase, oxygen-tracer experiments have shown that it is a monooxygnase, incorporating only one oxygen atom from molecular oxygen. The second oxygen atom that is incorporated into the product originates from a water molecule, which is regenerated during the reaction and thus does not show up in the reaction equation. Formerly EC 1.14.12.4.
Cross-references
BRENDA	1.14.13.242
EC2PDB	1.14.13.242
ExplorEnz	1.14.13.242
PRIAM enzyme-specific profiles	1.14.13.242
KEGG Ligand Database for Enzyme Nomenclature	1.14.13.242
IUBMB Enzyme Nomenclature	1.14.13.242
IntEnz	1.14.13.242
MEDLINE	Find literature relating to 1.14.13.242
MetaCyc	1.14.13.242