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ENZYME entry: EC 1.14.13.242

Accepted Name
3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase.
Alternative Name(s)
3-hydroxy-2-methylpyridinecarboxylate dioxygenase.
methylhydroxypyridine carboxylate dioxygenase.
methylhydroxypyridinecarboxylate oxidase.
MHPCO.
Reaction catalysed
  • 3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 <=> 2-(acetamidomethylene)succinate + NAD(+)
  • 3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 <=> 2-(acetamidomethylene)succinate + NADP(+)
Comment(s)
  • The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and Mesorhizobium loti, participates in the degradation of pyridoxine (vitamin B6).
  • Although the enzyme was initially thought to be a dioxygenase, oxygen-tracer experiments have shown that it is a monooxygnase, incorporating only one oxygen atom from molecular oxygen.
  • The second oxygen atom that is incorporated into the product originates from a water molecule, which is regenerated during the reaction and thus does not show up in the reaction equation.
  • Formerly EC 1.14.12.4.
Cross-references
BRENDA1.14.13.242
EC2PDB1.14.13.242
ExplorEnz1.14.13.242
PRIAM enzyme-specific profiles1.14.13.242
KEGG Ligand Database for Enzyme Nomenclature1.14.13.242
IUBMB Enzyme Nomenclature1.14.13.242
IntEnz1.14.13.242
MEDLINEFind literature relating to 1.14.13.242
MetaCyc1.14.13.242
Rhea expert-curated reactions1.14.13.242

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.13.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-