ENZYME entry: EC 1.14.13.242
| Accepted Name |
|---|
| 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase.
|
| Alternative Name(s) |
|---|
| 3-hydroxy-2-methylpyridinecarboxylate dioxygenase. |
| methylhydroxypyridine carboxylate dioxygenase. |
| methylhydroxypyridinecarboxylate oxidase. |
| MHPCO. |
| Reaction catalysed |
|---|
- 3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 <=> 2-(acetamidomethylene)succinate + NAD(+)
- 3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 <=> 2-(acetamidomethylene)succinate + NADP(+)
|
| Comment(s) |
|---|
- The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and
Mesorhizobium loti, participates in the degradation of pyridoxine
(vitamin B6).
- Although the enzyme was initially thought to be a dioxygenase,
oxygen-tracer experiments have shown that it is a monooxygnase,
incorporating only one oxygen atom from molecular oxygen.
- The second oxygen atom that is incorporated into the product
originates from a water molecule, which is regenerated during the
reaction and thus does not show up in the reaction equation.
- Formerly EC 1.14.12.4.
|
| Cross-references |
|---|
| BRENDA | 1.14.13.242 |
| EC2PDB | 1.14.13.242 |
| ExplorEnz | 1.14.13.242 |
| PRIAM enzyme-specific profiles | 1.14.13.242 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.242 |
| IUBMB Enzyme Nomenclature | 1.14.13.242 |
| IntEnz | 1.14.13.242 |
| MEDLINE | Find literature relating to 1.14.13.242 |
| MetaCyc | 1.14.13.242 |
| Rhea expert-curated reactions | 1.14.13.242 |
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