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ENZYME

ENZYME entry: EC 1.14.13.247

PURL: https://purl.expasy.org/enzyme/EC/1.14.13.247
Accepted Name
stachydrine N-demethylase
Alternative Name(s)
L-proline betaine N-demethylase
Reaction catalysed
  • L-proline betaine + NADPH + O2 + H(+) = N-methyl-L-proline + formaldehyde + NADP(+) + H2O
  • L-proline betaine + NADH + O2 + H(+) = N-methyl-L-proline + formaldehyde + NAD(+) + H2O
Comment(s)
  • The enzyme, characterized from the bacterium Sinorhizobium meliloti 1021, consists of three different types of subunits.
  • The catalytic unit contains a Rieske [2Fe-2S] iron-sulfur cluster, and catalyzes the monooxygenation of a methyl group.
  • The resulting N-methoxyl group is unstable and decomposes spontaneously to form formaldehyde.
  • The other subunits are involved in the transfer of electrons from NAD(P)H to the catalytic subunit.
Cross-references
BRENDA1.14.13.247
EC2PDB1.14.13.247
ExplorEnz1.14.13.247
KEGG Ligand Database for Enzyme Nomenclature1.14.13.247
IUBMB Enzyme Nomenclature1.14.13.247
MEDLINEFind literature relating to 1.14.13.247
MetaCyc1.14.13.247
Rhea expert-curated reactions1.14.13.247
UniProtKB/Swiss-Prot
Q92ZP9, STC2_RHIME

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