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ENZYME entry: EC

Accepted Name
stachydrine N-demethylase.
Alternative Name(s)
L-proline betaine N-demethylase.
Reaction catalysed
  • H(+) + L-proline betaine + NADPH + O2 <=> formaldehyde + H2O + N-methyl-L-proline + NADP(+)
  • H(+) + L-proline betaine + NADH + O2 <=> formaldehyde + H2O + N-methyl-L-proline + NAD(+)
  • The enzyme, characterized from the bacterium Sinorhizobium meliloti 1021, consists of three different types of subunits.
  • The catalytic unit contains a Rieske [2Fe-2S] iron-sulfur cluster, and catalyzes the monooxygenation of a methyl group.
  • The resulting N-methoxyl group is unstable and decomposes spontaneously to form formaldehyde.
  • The other subunits are involved in the transfer of electrons from NAD(P)H to the catalytic subunit.
PRIAM enzyme-specific profiles1.14.13.247
KEGG Ligand Database for Enzyme Nomenclature1.14.13.247
IUBMB Enzyme Nomenclature1.14.13.247
MEDLINEFind literature relating to
Rhea expert-curated reactions1.14.13.247

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
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