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ENZYME entry: EC 1.14.13.247

Accepted Name
Stachydrine N-demethylase.
Alternative Name(s)
L-proline betaine N-demethylase.
Reaction catalysed
L-proline betaine + NAD(P)H + O(2) <=> N-methyl-L-proline + formaldehyde + NAD(P)(+) + H(2)O
Comment(s)
  • The enzyme, characterized from the bacterium Sinorhizobium meliloti 1021, consists of three different types of subunits.
  • The catalytic unit contains a Rieske [2Fe-2S] iron-sulfur cluster, and catalyzes the monooxygenation of a methyl group.
  • The resulting N-methoxyl group is unstable and decomposes spontaneously to form formaldehyde.
  • The other subunits are involved in the transfer of electrons from NAD(P)H to the catalytic subunit.
Cross-references
BRENDA1.14.13.247
EC2PDB1.14.13.247
ExplorEnz1.14.13.247
PRIAM enzyme-specific profiles1.14.13.247
KEGG Ligand Database for Enzyme Nomenclature1.14.13.247
IUBMB Enzyme Nomenclature1.14.13.247
IntEnz1.14.13.247
MEDLINEFind literature relating to 1.14.13.247
MetaCyc1.14.13.247
Rhea expert-curated reactions1.14.13.247

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