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ENZYME

ENZYME entry: EC 1.14.14.1

Accepted Name
unspecific monooxygenase
Alternative Name(s)
aryl-4-monooxygenase
aryl hydrocarbon hydroxylase
cytochrome P450
flavoprotein-linked monooxygenase
microsomal monooxygenase
microsomal P450
xenobiotic monooxygenase
Reaction catalysed
an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] <=> an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups.
  • Together with EC 1.6.2.4, it forms a system in which two reducing equivalents are supplied by NADPH.
  • Some of the reactions attributed to EC 1.14.15.3 belong here.
  • Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1.
Cross-references
BRENDA1.14.14.1
EC2PDB1.14.14.1
ExplorEnz1.14.14.1
PRIAM enzyme-specific profiles1.14.14.1
KEGG Ligand Database for Enzyme Nomenclature1.14.14.1
IUBMB Enzyme Nomenclature1.14.14.1
IntEnz1.14.14.1
MEDLINEFind literature relating to 1.14.14.1
MetaCyc1.14.14.1
Rhea expert-curated reactions1.14.14.1
UniProtKB/Swiss-Prot
A0A3G9HRC2, ALT2_ALTALQ81BF4, C102_BACCRQ9PVE8, C330_FUNHE
Q98T91, C340_ORYLAQ8AXY5, C356_FUNHEQ2UNA2, C505_ASPOR
Q9Y8G7, C505_FUSOXO23066, C86A2_ARATHQ9LMM1, C86A4_ARATH
Q9CAD6, C86A7_ARATHO80823, C86A8_ARATHQ3LFU0, CP1A1_BALAC
P56590, CP1A1_CANLFQ06367, CP1A1_CAVPOQ92039, CP1A1_CHACA
O42231, CP1A1_CHEAUQ9W683, CP1A1_CHESAP79716, CP1A1_DICLA
Q5KQT7, CP1A1_FELCAP04798, CP1A1_HUMANO42430, CP1A1_LIMLI
P33616, CP1A1_MACFAQ6GUR1, CP1A1_MACMUQ00557, CP1A1_MESAU
Q92148, CP1A1_MICTOP00184, CP1A1_MOUSEQ92110, CP1A1_ONCMY
Q92095, CP1A1_OPSTAQ6JZS3, CP1A1_ORYLAP98181, CP1A1_PAGMA
Q9YH64, CP1A1_PLAFEQ92100, CP1A1_PLEPLP05176, CP1A1_RABIT
P00185, CP1A1_RATP56591, CP1A1_SHEEPO42457, CP1A1_SPAAU
Q92116, CP1A1_STECHQ3LFT9, CP1A2_BALACO77810, CP1A2_CALJA
P56592, CP1A2_CANLFQ64391, CP1A2_CAVPOQ01741, CP1A2_CHICK
Q5KQT6, CP1A2_FELCAP05177, CP1A2_HUMANO77809, CP1A2_MACFA
Q4H4C3, CP1A2_MACFUP24453, CP1A2_MESAUP00186, CP1A2_MOUSE
Q5RBQ1, CP1A2_PONABP00187, CP1A2_RABITP04799, CP1A2_RAT
Q92109, CP1A3_ONCMYP79760, CP1A4_CHICKP79761, CP1A5_CHICK
Q16678, CP1B1_HUMANQ64429, CP1B1_MOUSEQ64678, CP1B1_RAT
P56654, CP237_MOUSEP56655, CP238_MOUSEP56656, CP239_MOUSE
O62671, CP241_CANLFP79402, CP242_PIGQ6XVG2, CP254_MOUSE
Q9D816, CP255_MOUSEP33273, CP255_RATQ6V0L0, CP26C_HUMAN
B2RXA7, CP26C_MOUSEP11711, CP2A1_RATP15149, CP2A2_RAT
P20812, CP2A3_RATP15392, CP2A4_MOUSEP20852, CP2A5_MOUSE
P20853, CP2A7_HUMANP80055, CP2A7_PAPSPP24454, CP2A8_MESAU
P24455, CP2A9_MESAUQ05555, CP2AA_RABITQ05556, CP2AB_RABIT
P56593, CP2AC_MOUSEQ16696, CP2AD_HUMANP22779, CP2AX_BOVIN
P00176, CP2B1_RATP04167, CP2B2_RATP13107, CP2B3_RAT
P00178, CP2B4_RABITP12789, CP2B5_RABITP12790, CP2B9_MOUSE
P12791, CP2BA_MOUSEP24460, CP2BB_CANLFP33272, CP2BC_RAT
Q64583, CP2BF_RATO55071, CP2BJ_MOUSEP34033, CP2BX_CAVPO
P00180, CP2C1_RABITP00181, CP2C2_RABITP00182, CP2C3_RABIT
P11371, CP2C4_RABITP00179, CP2C5_RABITP05178, CP2C6_RAT
P05179, CP2C7_RATP10632, CP2C8_HUMANP11712, CP2C9_HUMAN
P08683, CP2CB_RATP11510, CP2CC_RATP20814, CP2CD_RAT
P17666, CP2CE_RABITP11372, CP2CF_RABITP15123, CP2CG_RABIT
P33260, CP2CI_HUMANP33261, CP2CJ_HUMANP33262, CP2CK_MACFA
P56594, CP2CL_CANLFQ08078, CP2CP_MESAUP33263, CP2CQ_MESAU
P33264, CP2CR_MESAUP33265, CP2CS_MESAUQ64458, CP2CT_MOUSE
Q29510, CP2CU_RABITQ29478, CP2CV_CAPHEP10633, CP2D1_RAT
P12938, CP2D3_RATQ64680, CP2D4_RATA0A087X1C5, CP2D7_HUMAN
P11714, CP2D9_MOUSEP24456, CP2DA_MOUSEP12939, CP2DA_RAT
P24457, CP2DB_MOUSEQ01361, CP2DE_BOVINQ29473, CP2DF_CANLF
Q64403, CP2DG_CAVPOQ29488, CP2DH_MACFAO18992, CP2DJ_CALJA
Q8CIM7, CP2DQ_MOUSEP10634, CP2DQ_RATO18963, CP2E1_BOVIN
Q9MZY0, CP2E1_CANLFP05181, CP2E1_HUMANP33266, CP2E1_MACFA
Q6GUQ4, CP2E1_MACMUP51581, CP2E1_MESAUQ05421, CP2E1_MOUSE
P79383, CP2E1_PIGP08682, CP2E1_RABITP05182, CP2E1_RAT
P24903, CP2F1_HUMANO18809, CP2F3_CAPHIQ8WNE1, CP2F5_GORGO
P24461, CP2G1_RABITP10610, CP2G1_RATP05180, CP2H1_CHICK
P20678, CP2H2_CHICKP52786, CP2J1_RABITP51590, CP2J3_RAT
Q9QXF7, CP2J4_RATO54749, CP2J5_MOUSEO54750, CP2J6_MOUSE
Q92090, CP2K1_ONCMYO93299, CP2K3_ONCMYO93297, CP2K4_ONCMY
Q27712, CP2L1_PANARQ92088, CP2M1_ONCMYQ9JMA7, CP341_MOUSE
Q9HB55, CP343_HUMANP04800, CP3A1_RATP05183, CP3A2_RAT
P08684, CP3A4_HUMANP20815, CP3A5_HUMANP80056, CP3A5_PAPSP
P11707, CP3A6_RABITP24462, CP3A7_HUMANP33268, CP3A8_MACFA
P51538, CP3A9_RATQ64459, CP3AB_MOUSEP24463, CP3AC_CANLF
Q64464, CP3AD_MOUSEQ64417, CP3AE_CAVPOQ64406, CP3AF_CAVPO
Q64481, CP3AG_MOUSEQ64409, CP3AH_CAVPOQ64581, CP3AI_RAT
P79152, CP3AJ_CAPHEO18993, CP3AL_CALJAQ29496, CP3AO_SHEEP
O09158, CP3AP_MOUSEO42563, CP3AR_ONCMYP79102, CP3AS_BOVIN
P79401, CP3AT_PIGO70537, CP3AV_MESAUP10611, CP4A4_RABIT
Q02928, CP4AB_HUMANP24464, CP4AC_RATP13584, CP4B1_HUMAN
Q64462, CP4B1_MOUSEP15128, CP4B1_RABITP15129, CP4B1_RAT
P29981, CP4C1_BLADIQ91WL5, CP4CA_MOUSEA2A974, CP4CB_MOUSE
Q964T1, CP4CU_BLAGEP78329, CP4F2_HUMANQ08477, CP4F3_HUMAN
P51870, CP4F5_RATP51871, CP4F6_RATP98187, CP4F8_HUMAN
Q9HBI6, CP4FB_HUMANQ9HCS2, CP4FC_HUMANQ86W10, CP4Z1_HUMAN
P13527, CP6A1_MUSDOQ04552, CP6B1_PAPPOQ27664, CP6B2_HELAM
Q27756, CP6B3_PAPPOQ27902, CP6B4_PAPGLQ95036, CP6B5_PAPGL
Q95031, CP6B6_HELAMO61387, CP6B7_HELAMP14779, CPXB_PRIM2
Q91X77, CY250_MOUSEO08336, CYPB_BACSUO08394, CYPD_BACSU
Q9HGE0, FUM6_GIBM7

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
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