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ENZYME

ENZYME entry: EC 1.6.2.4

PURL: https://purl.expasy.org/enzyme/EC/1.6.2.4
Accepted Name
NADPH--hemoprotein reductase
Alternative Name(s)
aldehyde reductase (NADPH-dependent)
CPR
cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent)
cytochrome P450 reductase
dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase
FAD-cytochrome c reductase
ferrihemoprotein P-450 reductase
NADP--cytochrome c reductase
NADP--cytochrome reductase
NADPH:ferrihemoprotein oxidoreductase
NADPH:P450 reductase
NADPH--cytochrome c oxidoreductase
NADPH--cytochrome c reductase
NADPH--cytochrome P450 oxidoreductase
NADPH--cytochrome P450 reductase
NADPH-dependent cytochrome c reductase
NADPH--ferricytochrome c oxidoreductase
NADPH--ferrihemoprotein reductase
reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase
reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate)
TPNH2 cytochrome c reductase
TPNH-cytochrome c reductase
Reaction catalysed
2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)
Comment(s)
  • This enzyme catalyzes the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN.
  • It also reduces cytochrome b5 and cytochrome c.
  • The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.
Cross-references
BRENDA1.6.2.4
EC2PDB1.6.2.4
ExplorEnz1.6.2.4
KEGG Ligand Database for Enzyme Nomenclature1.6.2.4
IUBMB Enzyme Nomenclature1.6.2.4
MEDLINEFind literature relating to 1.6.2.4
MetaCyc1.6.2.4
Rhea expert-curated reactions1.6.2.4
UniProtKB/Swiss-Prot
A0A3G9HRC2, ALT2_ALTALQ81BF4, C102_BACCRQ2UNA2, C505_ASPOR
Q9Y8G7, C505_FUSOXA0A7T9QPQ1, CPR_PIPNIP14779, CPXB_PRIM2
A0A0C3HJL3, CYAG1_OIDMZO08336, CYPB_BACSUI7ZK32, CYPC3_ASPO3
G5EJN7, CYPD6_PHACHO08394, CYPD_BACSUA2QLV1, CYPE1_ASPNC
Q0D1W9, CYPE3_ASPTNA0A0G4P2K0, CYPE4_PENC3A0A0A2J1Z6, CYPE4_PENEN
A0A101MN42, CYPE4_PENFRG7XMT1, CYPE5_ASPKWA0A100IM63, CYPE5_ASPNG
G9MLG2, CYPP1_HYPVGR0IGL9, CYPU2_EXST2Q9HGE0, FUM6_GIBM7
Q9SB48, NCPR1_ARATHA0A2U1LIM9, NCPR1_ARTANQ7X7K8, NCPR1_ORYSJ
Q9SUM3, NCPR2_ARATHA0A2U1KZS6, NCPR2_ARTANQ0J705, NCPR2_ORYSJ
Q653S9, NCPR3_ORYSJQ4WM67, NCPR_ASPFUA2QS05, NCPR_ASPNC
Q00141, NCPR_ASPNGQ2UHA7, NCPR_ASPORQ0CMM0, NCPR_ASPTN
Q3SYT8, NCPR_BOVINP50126, NCPR_CANMAP37201, NCPR_CANTR
Q05001, NCPR_CATROP37039, NCPR_CAVPOQ55CT1, NCPR_DICDI
Q27597, NCPR_DROMEQ5BFT5, NCPR_EMENIP16435, NCPR_HUMAN
P37040, NCPR_MOUSEQ07994, NCPR_MUSDOQ9HDG2, NCPR_PHACH
P04175, NCPR_PIGP00389, NCPR_RABITP00388, NCPR_RAT
P19618, NCPR_SALTRP36587, NCPR_SCHPOC5YJG8, NCPR_SORBI
P37116, NCPR_VIGRRP16603, NCPR_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.6.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.6.-.-
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