ENZYME entry: EC 1.6.2.4

Accepted Name

NADPH--hemoprotein reductase

Alternative Name(s)

aldehyde reductase (NADPH-dependent)

CPR

cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent)

cytochrome P450 reductase

dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase

FAD-cytochrome c reductase

ferrihemoprotein P-450 reductase

NADP--cytochrome c reductase

NADP--cytochrome reductase

NADPH:ferrihemoprotein oxidoreductase

NADPH:P450 reductase

NADPH--cytochrome c oxidoreductase

NADPH--cytochrome c reductase

NADPH--cytochrome P450 oxidoreductase

NADPH--cytochrome P450 reductase

NADPH-dependent cytochrome c reductase

NADPH--ferricytochrome c oxidoreductase

NADPH--ferrihemoprotein reductase

reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase

reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate)

TPNH2 cytochrome c reductase

TPNH-cytochrome c reductase

Reaction catalysed

NADPH + 2 oxidized [cytochrome P450] <=> H(+) + NADP(+) + 2 reduced [cytochrome P450]

Comment(s)

This enzyme catalyzes the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN.
It also reduces cytochrome b5 and cytochrome c.
The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.

Cross-references

BRENDA

1.6.2.4

EC2PDB

1.6.2.4

ExplorEnz

1.6.2.4

PRIAM enzyme-specific profiles

1.6.2.4

KEGG Ligand Database for Enzyme Nomenclature

1.6.2.4

IUBMB Enzyme Nomenclature

1.6.2.4

IntEnz

1.6.2.4

MEDLINE

Find literature relating to 1.6.2.4

MetaCyc

1.6.2.4

Rhea expert-curated reactions

1.6.2.4

UniProtKB/Swiss-Prot

A0A3G9HRC2, ALT2_ALTAL	Q81BF4, C102_BACCR	Q2UNA2, C505_ASPOR
Q9Y8G7, C505_FUSOX	A0A7T9QPQ1, C719A_PIPNI	P14779, CPXB_PRIM2
A0A0C3HJL3, CYAG1_OIDMZ	O08336, CYPB_BACSU	I7ZK32, CYPC3_ASPO3
G5EJN7, CYPD6_PHACH	O08394, CYPD_BACSU	A2QLV1, CYPE1_ASPNC
Q0D1W9, CYPE3_ASPTN	A0A0G4P2K0, CYPE4_PENC3	A0A0A2J1Z6, CYPE4_PENEN
A0A101MN42, CYPE4_PENFR	G7XMT1, CYPE5_ASPKW	A0A100IM63, CYPE5_ASPNG
G9MLG2, CYPP1_HYPVG	R0IGL9, CYPU2_EXST2	Q9HGE0, FUM6_GIBM7
Q9SB48, NCPR1_ARATH	A0A2U1LIM9, NCPR1_ARTAN	Q7X7K8, NCPR1_ORYSJ
Q9SUM3, NCPR2_ARATH	A0A2U1KZS6, NCPR2_ARTAN	Q0J705, NCPR2_ORYSJ
Q653S9, NCPR3_ORYSJ	Q4WM67, NCPR_ASPFU	A2QS05, NCPR_ASPNC
Q00141, NCPR_ASPNG	Q2UHA7, NCPR_ASPOR	Q0CMM0, NCPR_ASPTN
Q3SYT8, NCPR_BOVIN	P50126, NCPR_CANMA	P37201, NCPR_CANTR
Q05001, NCPR_CATRO	P37039, NCPR_CAVPO	Q55CT1, NCPR_DICDI
Q27597, NCPR_DROME	Q5BFT5, NCPR_EMENI	P16435, NCPR_HUMAN
P37040, NCPR_MOUSE	Q07994, NCPR_MUSDO	Q9HDG2, NCPR_PHACH
P04175, NCPR_PIG	P00389, NCPR_RABIT	P00388, NCPR_RAT
P19618, NCPR_SALTR	P36587, NCPR_SCHPO	C5YJG8, NCPR_SORBI
P37116, NCPR_VIGRR	P16603, NCPR_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.6.2.-
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