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ENZYME entry: EC 1.14.14.105

Accepted Name
Taxane 10-beta-hydroxylase.
Alternative Name(s)
5-alpha-taxadienol-10-beta-hydroxylase.
CYP725A1.
Reaction catalysed
Taxa-4(20),11-dien-5-alpha-yl acetate + [reduced NADPH--hemoprotein reductase] + O(2) <=> 10-beta-hydroxytaxa-4(20),11-dien-5-alpha-yl acetate + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • This microsomal cytochrome-P450 (heme-thiolate) enzyme from the plant Taxus cuspidata is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel).
  • Formerly EC 1.14.13.76.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.105
EC2PDB1.14.14.105
ExplorEnz1.14.14.105
PRIAM enzyme-specific profiles1.14.14.105
KEGG Ligand Database for Enzyme Nomenclature1.14.14.105
IUBMB Enzyme Nomenclature1.14.14.105
IntEnz1.14.14.105
MEDLINEFind literature relating to 1.14.14.105
MetaCyc1.14.14.105
UniProtKB/Swiss-Prot
Q9AXM6, T10H_TAXCU

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