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ENZYME entry: EC 1.14.14.13

Accepted Name
4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase.
Reaction catalysed
4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 <=> 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O
Comment(s)
  • Catalyzes a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family.
  • Forms a complex with a dedicated NAD(P)H:FMN oxidoreductase.
  • The enzyme is not able to hydroxylate free substrates, activation by the acyl-carrier protein is mandatory.
  • Octanoyl-S-[BtrI acyl-carrier protein] is also accepted.
Cross-references
BRENDA1.14.14.13
EC2PDB1.14.14.13
ExplorEnz1.14.14.13
PRIAM enzyme-specific profiles1.14.14.13
KEGG Ligand Database for Enzyme Nomenclature1.14.14.13
IUBMB Enzyme Nomenclature1.14.14.13
IntEnz1.14.14.13
MEDLINEFind literature relating to 1.14.14.13
MetaCyc1.14.14.13
Rhea expert-curated reactions1.14.14.13
UniProtKB/Swiss-Prot
Q4H4E5, BTRO_NIACI;  Q4H4E3, BTRV_NIACI;  

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