ENZYME entry: EC 1.14.14.13
| Accepted Name |
|---|
| 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein]
monooxygenase.
|
| Reaction catalysed |
|---|
| 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] + FMNH(2) + O(2) <=> 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] + FMN + H(2)O |
| Cofactor(s) |
|---|
| FMNH(2).
|
| Comment(s) |
|---|
- Catalyzes a step in the biosynthesis of the side chain of the
aminoglycoside antibiotics of the butirosin family.
- Forms a complex with a dedicated NAD(P)H:FMN oxidoreductase.
- The enzyme is not able to hydroxylate free substrates, activation by
the acyl-carrier protein is mandatory.
- Octanoyl-S-[BtrI acyl-carrier protein] is also accepted.
|
| Cross-references |
|---|
| BRENDA | 1.14.14.13 |
| EC2PDB | 1.14.14.13 |
| ExplorEnz | 1.14.14.13 |
| PRIAM enzyme-specific profiles | 1.14.14.13 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.13 |
| IUBMB Enzyme Nomenclature | 1.14.14.13 |
| IntEnz | 1.14.14.13 |
| MEDLINE | Find literature relating to 1.14.14.13 |
| MetaCyc | 1.14.14.13 |
| UniProtKB/Swiss-Prot |
|
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