Expasy logo

ENZYME

ENZYME entry: EC 1.14.14.13

Accepted Name
4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase
Reaction catalysed
4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 = 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O
Comment(s)
  • Catalyzes a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family.
  • Forms a complex with a dedicated NAD(P)H:FMN oxidoreductase.
  • The enzyme is not able to hydroxylate free substrates, activation by the acyl-carrier protein is mandatory.
  • Octanoyl-S-[BtrI acyl-carrier protein] is also accepted.
Cross-references
BRENDA1.14.14.13
EC2PDB1.14.14.13
ExplorEnz1.14.14.13
PRIAM enzyme-specific profiles1.14.14.13
KEGG Ligand Database for Enzyme Nomenclature1.14.14.13
IUBMB Enzyme Nomenclature1.14.14.13
IntEnz1.14.14.13
MEDLINEFind literature relating to 1.14.14.13
MetaCyc1.14.14.13
Rhea expert-curated reactions1.14.14.13
UniProtKB/Swiss-Prot
Q4H4E5, BTRO_NIACIQ4H4E3, BTRV_NIACI

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-