ENZYME

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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.14.13

Accepted Name

4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase.

Reaction catalysed

4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] + FMNH(2) + O(2) <=> 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] + FMN + H(2)O

Cofactor(s)

FMNH(2).

Comment(s)

Catalyzes a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family.
Forms a complex with a dedicated NAD(P)H:FMN oxidoreductase.
The enzyme is not able to hydroxylate free substrates, activation by the acyl-carrier protein is mandatory.
Octanoyl-S-[BtrI acyl-carrier protein] is also accepted.

Cross-references

BRENDA

1.14.14.13

EC2PDB

1.14.14.13

ExplorEnz

1.14.14.13

PRIAM enzyme-specific profiles

1.14.14.13

KEGG Ligand Database for Enzyme Nomenclature

1.14.14.13

IUBMB Enzyme Nomenclature