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ENZYME

ENZYME entry: EC 1.14.14.132

Accepted Name
(-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase
Alternative Name(s)
CYP82D61
Reaction catalysed
(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] = 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein characterized from the plant Sinopodophyllum hexandrum.
  • The enzyme produces the direct precursor to etoposide, a potent anticancer drug.
  • It can also act on (-)-deoxypodophyllotoxin with lower efficiency.
  • Formerly EC 1.14.13.214.
Cross-references
BRENDA1.14.14.132
EC2PDB1.14.14.132
ExplorEnz1.14.14.132
PRIAM enzyme-specific profiles1.14.14.132
KEGG Ligand Database for Enzyme Nomenclature1.14.14.132
IUBMB Enzyme Nomenclature1.14.14.132
IntEnz1.14.14.132
MEDLINEFind literature relating to 1.14.14.132
MetaCyc1.14.14.132
Rhea expert-curated reactions1.14.14.132
UniProtKB/Swiss-Prot
A0A0N7F297, C82D6_SINHE

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