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ENZYME entry: EC 1.14.14.143

Accepted Name
(+)-menthofuran synthase.
Alternative Name(s)
(+)-MFS.
(+)-pulegone 9-hydroxylase.
Menthofuran synthase.
Reaction catalysed
(+)-pulegone + [reduced NADPH--hemoprotein reductase] + O(2) <=> (+)-menthofuran + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein.
  • The conversion of substrate into product involves the hydroxylation of the syn-methyl (C(9)), intramolecular cyclization to the hemiketal and dehydration to the furan.
  • This is the second cytochrome P450-mediated step of monoterpene metabolism in peppermint, with the other step being catalyzed by EC 1.14.14.99.
  • Formerly EC 1.14.13.104.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.143
EC2PDB1.14.14.143
ExplorEnz1.14.14.143
PRIAM enzyme-specific profiles1.14.14.143
KEGG Ligand Database for Enzyme Nomenclature1.14.14.143
IUBMB Enzyme Nomenclature1.14.14.143
IntEnz1.14.14.143
MEDLINEFind literature relating to 1.14.14.143
MetaCyc1.14.14.143
UniProtKB/Swiss-Prot
Q947B7, MFS_MENPI

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