Expasy logo

ENZYME

ENZYME entry: EC 1.14.14.143

Accepted Name
(+)-menthofuran synthase
Alternative Name(s)
(+)-MFS
(+)-pulegone 9-hydroxylase
menthofuran synthase
Reaction catalysed
(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] = (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein.
  • The conversion of substrate into product involves the hydroxylation of the syn-methyl (C9), intramolecular cyclization to the hemiketal and dehydration to the furan.
  • This is the second cytochrome P450-mediated step of monoterpene metabolism in peppermint, with the other step being catalyzed by EC 1.14.14.99.
  • Formerly EC 1.14.13.104.
Cross-references
BRENDA1.14.14.143
EC2PDB1.14.14.143
ExplorEnz1.14.14.143
PRIAM enzyme-specific profiles1.14.14.143
KEGG Ligand Database for Enzyme Nomenclature1.14.14.143
IUBMB Enzyme Nomenclature1.14.14.143
IntEnz1.14.14.143
MEDLINEFind literature relating to 1.14.14.143
MetaCyc1.14.14.143
Rhea expert-curated reactions1.14.14.143
UniProtKB/Swiss-Prot
Q947B7, MFS_MENPI

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-