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ENZYME entry: EC 1.14.14.150

Accepted Name
Costunolide synthase.
Alternative Name(s)
CYP71BL2.
Reaction catalysed
Germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH--hemoprotein reductase] + O(2) <=> (+)-costunolide + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein from chicory plants.
  • The enzyme hydroxylates carbon C-6 of germacra-1(10),4,11(13)-trien- 12-oate to give 6-alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate, which spontaneously cyclises to form the lactone ring.
  • Formerly EC 1.14.13.120.
Cross-references
BRENDA1.14.14.150
EC2PDB1.14.14.150
ExplorEnz1.14.14.150
PRIAM enzyme-specific profiles1.14.14.150
KEGG Ligand Database for Enzyme Nomenclature1.14.14.150
IUBMB Enzyme Nomenclature1.14.14.150
IntEnz1.14.14.150
MEDLINEFind literature relating to 1.14.14.150
MetaCyc1.14.14.150
UniProtKB/Swiss-Prot
F8S1I0, C7BL2_LACSA;  X2JE85, C7BL2_TANPA;  G3GBK0, C7BL3_CICIN;  

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