| Accepted Name |
|---|
| Sterol 14-alpha-demethylase.
|
| Alternative Name(s) |
|---|
| CYP51. |
| Cytochrome P450 51. |
| Lanosterol 14-alpha-demethylase. |
| Lanosterol 14-demethylase. |
| Obtusufoliol 14-demethylase. |
| Reaction catalysed |
|---|
| A 14-alpha-methylsteroid + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) <=> a Delta(14)-steroid + formate + 3 [oxidized NADPH--hemoprotein reductase] + 4 H(2)O |
| Cofactor(s) |
|---|
| Heme-thiolate.
|
| Comment(s) |
|---|
- This cytochrome P450 (heme-thiolate) enzyme acts on a range of
steroids with a 14-alpha-methyl group, such as obtusifoliol and
lanosterol.
- The enzyme catalyzes a hydroxylation and a reduction of the 14-alpha-
methyl group, followed by a second hydroxylation, resulting in the
elimination of formate and formation of a 14(15) double bond.
- Formerly EC 1.14.13.70.
|
| Cross-references |
|---|
| PROSITE | PDOC00081 |
| BRENDA | 1.14.14.154 |
| EC2PDB | 1.14.14.154 |
| ExplorEnz | 1.14.14.154 |
| PRIAM enzyme-specific profiles | 1.14.14.154 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.154 |
| IUBMB Enzyme Nomenclature | 1.14.14.154 |
| IntEnz | 1.14.14.154 |
| MEDLINE | Find literature relating to 1.14.14.154 |
| MetaCyc | 1.14.14.154 |
| Rhea expert-curated reactions | 1.14.14.154 |
| UniProtKB/Swiss-Prot |
| Q9SAA9, CP511_ARATH; | B8N2C8, CP51A_ASPFN; | Q4WNT5, CP51A_ASPFU; |
| Q4PJW3, CP51A_BOVIN; | Q16850, CP51A_HUMAN; | Q4R8S6, CP51A_MACFA; |
| Q8K0C4, CP51A_MOUSE; | O46420, CP51A_PIG; | Q5RE72, CP51A_PONAB; |
| Q64654, CP51A_RAT; | B8NFL5, CP51B_ASPFN; | E9QY26, CP51B_ASPFU; |
| B8NUK6, CP51C_ASPFN; | Q759W0, CP51_ASHGO; | P10613, CP51_CANAL; |
| P50859, CP51_CANGA; | P14263, CP51_CANTR; | Q9UVC3, CP51_CUNEL; |
| Q1ZXH9, CP51_DICDI; | Q5UQI3, CP51_MIMIV; | P0A513, CP51_MYCBO; |
| P9WPP8, CP51_MYCTO; | P9WPP9, CP51_MYCTU; | Q5IZM4, CP51_MYCVP; |
| Q12664, CP51_PENIT; | Q02315, CP51_PICKU; | Q09736, CP51_SCHPO; |
| P93846, CP51_SORBI; | Q7Z1V1, CP51_TRYCC; | O14442, CP51_UNCNE; |
| P49602, CP51_USTMA; | P93596, CP51_WHEAT; | P10614, CP51_YEAST; |
| Q1JPY5, CYP51_DANRE; |
|