Accepted Name |
Sterol 14-alpha-demethylase.
|
Alternative Name(s) |
CYP51. |
Cytochrome P450 51. |
Lanosterol 14-alpha-demethylase. |
Lanosterol 14-demethylase. |
Obtusufoliol 14-demethylase. |
Reaction catalysed |
A 14-alpha-methylsteroid + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) <=> a Delta(14)-steroid + formate + 3 [oxidized NADPH--hemoprotein reductase] + 4 H(2)O |
Cofactor(s) |
Heme-thiolate.
|
Comment(s) |
- This cytochrome P450 (heme-thiolate) enzyme acts on a range of
steroids with a 14-alpha-methyl group, such as obtusifoliol and
lanosterol.
- The enzyme catalyzes a hydroxylation and a reduction of the 14-alpha-
methyl group, followed by a second hydroxylation, resulting in the
elimination of formate and formation of a 14(15) double bond.
- Formerly EC 1.14.13.70.
|
Cross-references |
PROSITE | PDOC00081 |
BRENDA | 1.14.14.154 |
EC2PDB | 1.14.14.154 |
ExplorEnz | 1.14.14.154 |
PRIAM enzyme-specific profiles | 1.14.14.154 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.154 |
IUBMB Enzyme Nomenclature | 1.14.14.154 |
IntEnz | 1.14.14.154 |
MEDLINE | Find literature relating to 1.14.14.154 |
MetaCyc | 1.14.14.154 |
Rhea expert-curated reactions | 1.14.14.154 |
UniProtKB/Swiss-Prot |
Q9SAA9, CP511_ARATH; | B8N2C8, CP51A_ASPFN; | Q4WNT5, CP51A_ASPFU; |
Q4PJW3, CP51A_BOVIN; | I1RJR2, CP51A_GIBZE; | Q16850, CP51A_HUMAN; |
Q4R8S6, CP51A_MACFA; | Q8K0C4, CP51A_MOUSE; | O46420, CP51A_PIG; |
Q5RE72, CP51A_PONAB; | Q64654, CP51A_RAT; | B8NFL5, CP51B_ASPFN; |
E9QY26, CP51B_ASPFU; | I1RBR4, CP51B_GIBZE; | B8NUK6, CP51C_ASPFN; |
I1S2M5, CP51C_GIBZE; | Q759W0, CP51_ASHGO; | P10613, CP51_CANAL; |
P50859, CP51_CANGA; | P14263, CP51_CANTR; | Q9UVC3, CP51_CUNEL; |
Q1ZXH9, CP51_DICDI; | Q5UQI3, CP51_MIMIV; | P0A513, CP51_MYCBO; |
P9WPP8, CP51_MYCTO; | P9WPP9, CP51_MYCTU; | Q5IZM4, CP51_MYCVP; |
Q12664, CP51_PENIT; | Q02315, CP51_PICKU; | Q09736, CP51_SCHPO; |
P93846, CP51_SORBI; | Q7Z1V1, CP51_TRYCC; | O14442, CP51_UNCNE; |
P49602, CP51_USTMA; | P93596, CP51_WHEAT; | P10614, CP51_YEAST; |
Q1JPY5, CYP51_DANRE; |
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