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ENZYME

ENZYME entry: EC 1.14.14.154

Accepted Name
sterol 14alpha-demethylase
Alternative Name(s)
CYP51
cytochrome P450 51
lanosterol 14alpha-demethylase
lanosterol 14-demethylase
obtusufoliol 14-demethylase
Reaction catalysed
a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • This cytochrome P450 (heme-thiolate) enzyme acts on a range of steroids with a 14alpha-methyl group, such as obtusifoliol and lanosterol.
  • The enzyme catalyzes a hydroxylation and a reduction of the 14alpha- methyl group, followed by a second hydroxylation, resulting in the elimination of formate and formation of a 14(15) double bond.
  • Formerly EC 1.14.13.70.
Cross-references
BRENDA1.14.14.154
EC2PDB1.14.14.154
ExplorEnz1.14.14.154
PRIAM enzyme-specific profiles1.14.14.154
KEGG Ligand Database for Enzyme Nomenclature1.14.14.154
IUBMB Enzyme Nomenclature1.14.14.154
IntEnz1.14.14.154
MEDLINEFind literature relating to 1.14.14.154
MetaCyc1.14.14.154
Rhea expert-curated reactions1.14.14.154
UniProtKB/Swiss-Prot
Q9SAA9, CP511_ARATHB8N2C8, CP51A_ASPFNQ4WNT5, CP51A_ASPFU
Q4PJW3, CP51A_BOVINI1RJR2, CP51A_GIBZEQ16850, CP51A_HUMAN
Q4R8S6, CP51A_MACFAQ8K0C4, CP51A_MOUSEO46420, CP51A_PIG
Q5RE72, CP51A_PONABQ64654, CP51A_RATB8NFL5, CP51B_ASPFN
E9QY26, CP51B_ASPFUI1RBR4, CP51B_GIBZEB8NUK6, CP51C_ASPFN
I1S2M5, CP51C_GIBZEQ759W0, CP51_ASHGOP10613, CP51_CANAL
P50859, CP51_CANGBP14263, CP51_CANTRQ9UVC3, CP51_CUNEL
Q1ZXH9, CP51_DICDIQ5UQI3, CP51_MIMIVQ12664, CP51_PENIT
Q02315, CP51_PICKUQ09736, CP51_SCHPOP93846, CP51_SORBI
Q7Z1V1, CP51_TRYCCO14442, CP51_UNCNEP49602, CP51_USTMA
P93596, CP51_WHEATP10614, CP51_YEASTQ1JPY5, CYP51_DANRE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
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