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ENZYME entry: EC 1.14.14.154

Accepted Name
Sterol 14-alpha-demethylase.
Alternative Name(s)
CYP51.
Cytochrome P450 51.
Lanosterol 14-alpha-demethylase.
Lanosterol 14-demethylase.
Obtusufoliol 14-demethylase.
Reaction catalysed
A 14-alpha-methylsteroid + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) <=> a Delta(14)-steroid + formate + 3 [oxidized NADPH--hemoprotein reductase] + 4 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • This cytochrome P450 (heme-thiolate) enzyme acts on a range of steroids with a 14-alpha-methyl group, such as obtusifoliol and lanosterol.
  • The enzyme catalyzes a hydroxylation and a reduction of the 14-alpha- methyl group, followed by a second hydroxylation, resulting in the elimination of formate and formation of a 14(15) double bond.
  • Formerly EC 1.14.13.70.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.154
EC2PDB1.14.14.154
ExplorEnz1.14.14.154
PRIAM enzyme-specific profiles1.14.14.154
KEGG Ligand Database for Enzyme Nomenclature1.14.14.154
IUBMB Enzyme Nomenclature1.14.14.154
IntEnz1.14.14.154
MEDLINEFind literature relating to 1.14.14.154
MetaCyc1.14.14.154
Rhea expert-curated reactions1.14.14.154
UniProtKB/Swiss-Prot
Q9SAA9, CP511_ARATH;  B8N2C8, CP51A_ASPFN;  Q4WNT5, CP51A_ASPFU;  
Q4PJW3, CP51A_BOVIN;  Q16850, CP51A_HUMAN;  Q4R8S6, CP51A_MACFA;  
Q8K0C4, CP51A_MOUSE;  O46420, CP51A_PIG;  Q5RE72, CP51A_PONAB;  
Q64654, CP51A_RAT;  B8NFL5, CP51B_ASPFN;  E9QY26, CP51B_ASPFU;  
B8NUK6, CP51C_ASPFN;  Q759W0, CP51_ASHGO;  P10613, CP51_CANAL;  
P50859, CP51_CANGA;  P14263, CP51_CANTR;  Q9UVC3, CP51_CUNEL;  
Q1ZXH9, CP51_DICDI;  Q5UQI3, CP51_MIMIV;  P0A513, CP51_MYCBO;  
P9WPP8, CP51_MYCTO;  P9WPP9, CP51_MYCTU;  Q5IZM4, CP51_MYCVP;  
Q12664, CP51_PENIT;  Q02315, CP51_PICKU;  Q09736, CP51_SCHPO;  
P93846, CP51_SORBI;  Q7Z1V1, CP51_TRYCC;  O14442, CP51_UNCNE;  
P49602, CP51_USTMA;  P93596, CP51_WHEAT;  P10614, CP51_YEAST;  
Q1JPY5, CYP51_DANRE;  

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