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ENZYME entry: EC 1.14.14.156
Accepted Name |
tryptophan N-monooxygenase.
|
Alternative Name(s) |
CYP79B1. |
CYP79B2. |
CYP79B3. |
tryptophan N-hydroxylase. |
Reaction catalysed |
L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] |
Comment(s) |
- A cytochrome P450 (heme-thiolate) protein from the plant Arabidopsis
thaliana.
- This enzyme catalyzes two successive N-hydroxylations of
L-tryptophan, the first steps in the biosynthesis of both auxin and
the indole alkaloid phytoalexin camalexin.
- The product of the two hydroxylations, N,N-dihydroxy-L-tryptophan,
is extremely labile and dehydrates spontaneously.
- The dehydrated product is then subject to a decarboxylation that
produces an oxime.
- It is still not known whether the decarboxylation is spontaneous or
catalyzed by the enzyme.
- Formerly EC 1.14.13.125 and EC 1.14.13.n2.
|
Cross-references |
BRENDA | 1.14.14.156 |
EC2PDB | 1.14.14.156 |
ExplorEnz | 1.14.14.156 |
PRIAM enzyme-specific profiles | 1.14.14.156 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.156 |
IUBMB Enzyme Nomenclature | 1.14.14.156 |
IntEnz | 1.14.14.156 |
MEDLINE | Find literature relating to 1.14.14.156 |
MetaCyc | 1.14.14.156 |
Rhea expert-curated reactions | 1.14.14.156 |
UniProtKB/Swiss-Prot |
|
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