Expasy logo

ENZYME

ENZYME entry: EC 1.14.14.16

PURL: https://purl.expasy.org/enzyme/EC/1.14.14.16
Accepted Name
steroid 21-monooxygenase
Alternative Name(s)
CYP21A2
cytochrome p450 XXIA1
steroid 21-hydroxylase
Reaction catalysed
  • progesterone + reduced [NADPH--hemoprotein reductase] + O2 = 21-hydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
  • 17alpha-hydroxyprogesterone + reduced [NADPH--hemoprotein reductase] + O2 = 11-deoxycortisol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Comment(s)
  • for the conversion of progesterone and 17alpha-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol.
  • Involved in the biosynthesis of the hormones aldosterone and cortisol.
  • The electron donor is EC 1.6.2.4.
  • Formerly EC 1.14.1.8, EC 1.14.99.10 and EC 1.99.1.11.
Cross-references
BRENDA1.14.14.16
EC2PDB1.14.14.16
ExplorEnz1.14.14.16
KEGG Ligand Database for Enzyme Nomenclature1.14.14.16
IUBMB Enzyme Nomenclature1.14.14.16
MEDLINEFind literature relating to 1.14.14.16
MetaCyc1.14.14.16
Rhea expert-curated reactions1.14.14.16
UniProtKB/Swiss-Prot
P00191, CP21A_BOVINQ8WNW0, CP21A_CANLFQ2LCM1, CP21A_CANLU
Q2LA60, CP21A_FELCAP08686, CP21A_HUMANQ2LA59, CP21A_LYNLY
P03940, CP21A_MOUSEP15540, CP21A_PIGQ64562, CP21A_RAT

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-