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ENZYME

ENZYME entry: EC 1.14.14.16

Accepted Name
steroid 21-monooxygenase
Alternative Name(s)
CYP21A2
cytochrome p450 XXIA1
steroid 21-hydroxylase
Reaction catalysed
  • O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
  • 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • for the conversion of progesterone and 17alpha-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol.
  • Involved in the biosynthesis of the hormones aldosterone and cortisol.
  • The electron donor is EC 1.6.2.4.
  • Formerly EC 1.14.1.8, EC 1.14.99.10 and EC 1.99.1.11.
Cross-references
BRENDA1.14.14.16
EC2PDB1.14.14.16
ExplorEnz1.14.14.16
PRIAM enzyme-specific profiles1.14.14.16
KEGG Ligand Database for Enzyme Nomenclature1.14.14.16
IUBMB Enzyme Nomenclature1.14.14.16
IntEnz1.14.14.16
MEDLINEFind literature relating to 1.14.14.16
MetaCyc1.14.14.16
Rhea expert-curated reactions1.14.14.16
UniProtKB/Swiss-Prot
P00191, CP21A_BOVINQ8WNW0, CP21A_CANLFQ2LCM1, CP21A_CANLU
Q2LA60, CP21A_FELCAP08686, CP21A_HUMANQ2LA59, CP21A_LYNLY
P03940, CP21A_MOUSEP15540, CP21A_PIGQ64562, CP21A_RAT

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