Home  |  Contact

ENZYME entry: EC 1.14.14.168

Accepted Name
Germacreene A acid 8-beta-hydroxylase.
Alternative Name(s)
CYP71BL1.
CYP71BL6.
Reaction catalysed
Germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH--hemoprotein reductase] + O(2) <=> 8-beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH--hemoprotein reductase] + H(2)O
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein from the plant Helianthus annuus (common sunflower).
  • The cyclisation of 8-beta-hydroxygermacra-1(10),4,11(13)-triene-12- oate to inunolide (12,8-beta) does not seem to occur spontaneously.
  • The enzyme from Inula hupehensis also forms some 8-alpha- hydroxygermacra-1(10),4,11(13)-triene-12-oate, which spontaneously cyclises to 8-epi-inunolide (12,8-alpha) (cf. EC 1.14.14.170).
Cross-references
BRENDA1.14.14.168
EC2PDB1.14.14.168
ExplorEnz1.14.14.168
PRIAM enzyme-specific profiles1.14.14.168
KEGG Ligand Database for Enzyme Nomenclature1.14.14.168
IUBMB Enzyme Nomenclature1.14.14.168
IntEnz1.14.14.168
MEDLINEFind literature relating to 1.14.14.168
MetaCyc1.14.14.168
UniProtKB/Swiss-Prot
F8S1H3, C7BL1_HELAN;  A0A2H4DGV8, C7BL6_INUHU;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-