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ENZYME

ENZYME entry: EC 1.14.14.168

Accepted Name
germacreene A acid 8beta-hydroxylase
Alternative Name(s)
CYP71BL1
CYP71BL6
Reaction catalysed
germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein from the plant Helianthus annuus (common sunflower).
  • The cyclisation of 8beta-hydroxygermacra-1(10),4,11(13)-triene-12- oate to inunolide (12,8beta) does not seem to occur spontaneously.
  • The enzyme from Inula hupehensis also forms some 8alpha- hydroxygermacra-1(10),4,11(13)-triene-12-oate, which spontaneously cyclises to 8-epi-inunolide (12,8alpha) (cf. EC 1.14.14.170).
Cross-references
BRENDA1.14.14.168
EC2PDB1.14.14.168
ExplorEnz1.14.14.168
PRIAM enzyme-specific profiles1.14.14.168
KEGG Ligand Database for Enzyme Nomenclature1.14.14.168
IUBMB Enzyme Nomenclature1.14.14.168
IntEnz1.14.14.168
MEDLINEFind literature relating to 1.14.14.168
MetaCyc1.14.14.168
Rhea expert-curated reactions1.14.14.168
UniProtKB/Swiss-Prot
F8S1H3, C7BL1_HELANA0A2H4DGV8, C7BL6_INUHU

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