Home  |  Contact

ENZYME entry: EC 1.14.14.175

Accepted Name
Ferruginol synthase.
Alternative Name(s)
CYP76AH1.
Miltiradiene oxidase.
Reaction catalysed
Abieta-8,11,13-triene + [reduced NADPH--hemoprotein reductase] + O(2) <=> ferruginol + [oxidized NADPH--hemoprotein reductase] + H(2)O
Comment(s)
  • A cytochrome P450 (heme thiolate) enzyme found in some members of the Lamiaceae (mint family).
  • The enzyme from Rosmarinus officinalis (rosemary) is involved in biosynthesis of carnosic acid, while the enzyme from the Chinese medicinal herb Salvia miltiorrhiza is involved in the biosynthesis of the tanshinones, abietane-type norditerpenoid naphthoquinones that are the main lipophilic bioactive components found in the plant.
  • Formerly EC 1.14.13.190.
Cross-references
BRENDA1.14.14.175
EC2PDB1.14.14.175
ExplorEnz1.14.14.175
PRIAM enzyme-specific profiles1.14.14.175
KEGG Ligand Database for Enzyme Nomenclature1.14.14.175
IUBMB Enzyme Nomenclature1.14.14.175
IntEnz1.14.14.175
MEDLINEFind literature relating to 1.14.14.175
MetaCyc1.14.14.175
Rhea expert-curated reactions1.14.14.175
UniProtKB/Swiss-Prot
A0A0C5Q4Y6, C76H2_ROSOF;  A0A0C5QRZ2, C76H2_SALFT;  A0A0S1TP26, C76H2_SALPM;  
S4UX02, CYPH1_SALMI;  A0A1Z3GBS4, CYPH3_ISORU;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-