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ENZYME

ENZYME entry: EC 1.14.14.175

PURL: https://purl.expasy.org/enzyme/EC/1.14.14.175
Accepted Name
ferruginol synthase
Alternative Name(s)
CYP76AH1
miltiradiene oxidase
Reaction catalysed
abieta-8,11,13-triene + reduced [NADPH--hemoprotein reductase] + O2 = ferruginol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Comment(s)
  • A cytochrome P450 (heme thiolate) enzyme found in some members of the Lamiaceae (mint family).
  • The enzyme from Rosmarinus officinalis (rosemary) is involved in biosynthesis of carnosic acid, while the enzyme from the Chinese medicinal herb Salvia miltiorrhiza is involved in the biosynthesis of the tanshinones, abietane-type norditerpenoid naphthoquinones that are the main lipophilic bioactive components found in the plant.
  • Formerly EC 1.14.13.190.
Cross-references
BRENDA1.14.14.175
EC2PDB1.14.14.175
ExplorEnz1.14.14.175
KEGG Ligand Database for Enzyme Nomenclature1.14.14.175
IUBMB Enzyme Nomenclature1.14.14.175
MEDLINEFind literature relating to 1.14.14.175
MetaCyc1.14.14.175
Rhea expert-curated reactions1.14.14.175
UniProtKB/Swiss-Prot
A0A0C5Q4Y6, C76H2_ROSOFA0A0C5QRZ2, C76H2_SALFTA0A0S1TP26, C76H2_SALPM
S4UX02, CYPH1_SALMIA0A1Z3GBS4, CYPH3_ISORU

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