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ENZYME entry: EC 1.14.14.176

Accepted Name
Taxadiene 5-alpha-hydroxylase.
Reaction catalysed
Taxa-4,11-diene + [reduced NADPH--hemoprotein reductase] + O(2) <=> taxa-4(20),11-dien-5-alpha-ol + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • This microsomal cytochrome-P450 (heme-thiolate) enzyme is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel).
  • The reaction includes rearrangement of the 4(5)-double bond to a 4(20)-double bond, possibly through allylic oxidation.
  • Formerly EC 1.14.99.37.
Cross-references
BRENDA1.14.14.176
EC2PDB1.14.14.176
ExplorEnz1.14.14.176
PRIAM enzyme-specific profiles1.14.14.176
KEGG Ligand Database for Enzyme Nomenclature1.14.14.176
IUBMB Enzyme Nomenclature1.14.14.176
IntEnz1.14.14.176
MEDLINEFind literature relating to 1.14.14.176
MetaCyc1.14.14.176
Rhea expert-curated reactions1.14.14.176
UniProtKB/Swiss-Prot
Q6WG30, T5H_TAXCU

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