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ENZYME entry: EC 1.14.14.177

Accepted Name
Ultra-long-chain fatty acid omega-hydroxylase.
Alternative Name(s)
CYP4F22.
Reaction catalysed
An ultra-long-chain fatty acid + [reduced NADPH--hemoprotein reductase] + O(2) <=> an ultra-long-chain omega-hydroxy fatty acid + [oxidized NADPH--hemoprotein reductase] + H(2)O
Comment(s)
  • The enzyme, which is expressed in the epidermis of mammals, catalyzes the omega-hydroxylation of ultra-long-chain fatty acids (C(28) to C(36)).
  • The products are incorporated into acylceramides, epidermis-specific ceramide species that are very important for skin barrier formation.
Cross-references
BRENDA1.14.14.177
EC2PDB1.14.14.177
ExplorEnz1.14.14.177
PRIAM enzyme-specific profiles1.14.14.177
KEGG Ligand Database for Enzyme Nomenclature1.14.14.177
IUBMB Enzyme Nomenclature1.14.14.177
IntEnz1.14.14.177
MEDLINEFind literature relating to 1.14.14.177
MetaCyc1.14.14.177
Rhea expert-curated reactions1.14.14.177
UniProtKB/Swiss-Prot
Q6NT55, CP4FN_HUMAN

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