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ENZYME

ENZYME entry: EC 1.14.14.178

Accepted Name
steroid 22S-hydroxylase
Alternative Name(s)
CYP90B1
steroid C-22 hydroxylase
Reaction catalysed
  • a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
  • a C28-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a (22S)-22-hydroxy C28-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
  • a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • This plant cytochrome P450 (heme thiolate) enzyme participates in the biosynthesis of brassinosteroids.
  • While in vivo substrates include C28-steroids such as campestanol, campesterol, and 6-oxocampestanol, the enzyme is able to catalyze the C-22 hydroxylation of a variety of C27, C28 and C29 steroids.
Cross-references
BRENDA1.14.14.178
EC2PDB1.14.14.178
ExplorEnz1.14.14.178
PRIAM enzyme-specific profiles1.14.14.178
KEGG Ligand Database for Enzyme Nomenclature1.14.14.178
IUBMB Enzyme Nomenclature1.14.14.178
IntEnz1.14.14.178
MEDLINEFind literature relating to 1.14.14.178
MetaCyc1.14.14.178
Rhea expert-curated reactions1.14.14.178
UniProtKB/Swiss-Prot
O64989, C90B1_ARATHI1H7R8, C90B1_BRADIB8AJL3, C90B2_ORYSI
Q5CCK3, C90B2_ORYSJ

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