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ENZYME entry: EC 1.14.14.179

Accepted Name
brassinosteroid 6-oxygenase.
Alternative Name(s)
brassinosteroid 6-oxidase.
CYP85A1.
CYP85A2.
Reaction catalysed
6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • This cytochrome P450 (heme thiolate) plant enzyme catalyzes the C-6 hydoxylation of several brassinosteroid biosynthesis intermediates, and the further oxidation of the hydroxyl group to an oxo group.
  • Substrates include 6-deoxocastasterone, 6-deoxotyphasterol, 3-dehydro-6-deoxoteasterone, and 6-deoxoteasterone.
  • The CYP85A2 isozyme of Arabidopsis thaliana (but not the CYP85A1 isozyme) also catalyzes the activity of EC 1.14.14.180.
Cross-references
BRENDA1.14.14.179
EC2PDB1.14.14.179
ExplorEnz1.14.14.179
PRIAM enzyme-specific profiles1.14.14.179
KEGG Ligand Database for Enzyme Nomenclature1.14.14.179
IUBMB Enzyme Nomenclature1.14.14.179
IntEnz1.14.14.179
MEDLINEFind literature relating to 1.14.14.179
MetaCyc1.14.14.179
Rhea expert-curated reactions1.14.14.179

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
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