ENZYME entry: EC 1.14.14.184
| Accepted Name | ||
|---|---|---|
| 5-dehydro-6-demethoxyfumagillol synthase | ||
| Alternative Name(s) | ||
| Fma-P450 | ||
| fumagillin multifunctional cytochrome P450 monooxygenase | ||
| Reaction catalysed | ||
| (+)-exo-beta-bergamotene + 3 O2 + 2 reduced [NADPH--hemoprotein reductase] = 5-dehydro-6-demethoxyfumagillol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] | ||
| Comment(s) | ||
| The enzyme, characterized from the mold Aspergillus fumigatus, catalyzes a complex transformation comprising hydroxylation, bicyclic ring-opening, and two epoxidations, generating the sesquiterpenoid core skeleton of fumagillin. | ||
| Cross-references | ||
| BRENDA | 1.14.14.184 | |
| EC2PDB | 1.14.14.184 | |
| ExplorEnz | 1.14.14.184 | |
| PRIAM enzyme-specific profiles | 1.14.14.184 | |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.184 | |
| IUBMB Enzyme Nomenclature | 1.14.14.184 | |
| IntEnz | 1.14.14.184 | |
| MEDLINE | Find literature relating to 1.14.14.184 | |
| MetaCyc | 1.14.14.184 | |
| Rhea expert-curated reactions | 1.14.14.184 | |
| UniProtKB/Swiss-Prot |
| |
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