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ENZYME

ENZYME entry: EC 1.14.14.32

Accepted Name
17alpha-hydroxyprogesterone deacetylase
Alternative Name(s)
17alpha-hydroxyprogesterone 17,20-lyase
17alpha-hydroxyprogesterone acetaldehyde-lyase
CYP17
CYP17A1
Reaction catalysed
  • 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
  • 17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • A microsomal protein that catalyzes two independent reactions at the same active site - the 17-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis (EC 1.14.14.19), and the conversion of the 17-hydroxylated products via a 17,20-lyase reaction to form androstenedione and 3beta- hydroxyandrost-5-en-17-one, leading to sex hormone biosynthesis.
  • The activity of this reaction is dependent on the allosteric interaction of the enzyme with cytochrome b5 without any transfer of electrons from the cytochrome.
  • The enzymes from different organisms differ in their substrate specificity; while the enzymes from pig, hamster, and rat accept both 17alpha-hydroxyprogesterone and 17alpha-hydroxypregnenolone, the enzymes from human, bovine, sheep, goat, and bison do not accept the former, and the enzyme from guinea pig does not accept the latter.
  • Formerly EC 4.1.2.30.
Cross-references
BRENDA1.14.14.32
EC2PDB1.14.14.32
ExplorEnz1.14.14.32
PRIAM enzyme-specific profiles1.14.14.32
KEGG Ligand Database for Enzyme Nomenclature1.14.14.32
IUBMB Enzyme Nomenclature1.14.14.32
IntEnz1.14.14.32
MEDLINEFind literature relating to 1.14.14.32
MetaCyc1.14.14.32
Rhea expert-curated reactions1.14.14.32
UniProtKB/Swiss-Prot
Q9GMC7, CP17A_BISBIP05185, CP17A_BOVINQ9N0U7, CP17A_CAPHI
Q64410, CP17A_CAVPOP12394, CP17A_CHICKQ9GMC8, CP17A_FELCA
Q95328, CP17A_HORSEP05093, CP17A_HUMANO73853, CP17A_ICTPU
Q2XVA1, CP17A_MACFAQ8HYM9, CP17A_MACMUP70687, CP17A_MESAU
P27786, CP17A_MOUSEP30437, CP17A_ONCMYP70085, CP17A_ORYLA
Q8HYN1, CP17A_PANTRQ8HYN0, CP17A_PAPCYQ9GLD2, CP17A_PAPHU
Q91Z85, CP17A_PERLEP19100, CP17A_PIGO57525, CP17A_RANDY
P11715, CP17A_RATQ29497, CP17A_SHEEPQ92113, CP17A_SQUAC

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