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ENZYME

ENZYME entry: EC 1.14.14.19

Accepted Name
steroid 17alpha-monooxygenase
Alternative Name(s)
CYP17
CYP17A1
cytochrome p450 XVIIA1
steroid 17alpha-hydroxylase
steroid 17alpha-hydroxylase/17,20 lyase
Reaction catalysed
a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • Requires NADPH and EC 1.6.2.4.
  • Catalyzes two independent reactions at the same active site - the 17alpha-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis, and the conversion of the 17alpha-hydroxylated products via a 17,20-lyase reaction to form androstenedione and dehydroepiandrosterone, leading to sex hormone biosynthesis (EC 1.14.14.32).
  • The ratio of the 17alpha-hydroxylase and 17,20-lyase activities is an important factor in determining the directions of steroid hormone biosynthesis toward biosynthesis of glucocorticoid or sex hormones.
  • Formerly EC 1.14.1.7, EC 1.14.99.9 and EC 1.99.1.9.
Cross-references
BRENDA1.14.14.19
EC2PDB1.14.14.19
ExplorEnz1.14.14.19
PRIAM enzyme-specific profiles1.14.14.19
KEGG Ligand Database for Enzyme Nomenclature1.14.14.19
IUBMB Enzyme Nomenclature1.14.14.19
IntEnz1.14.14.19
MEDLINEFind literature relating to 1.14.14.19
MetaCyc1.14.14.19
Rhea expert-curated reactions1.14.14.19
UniProtKB/Swiss-Prot
Q9GMC7, CP17A_BISBIP05185, CP17A_BOVINQ9N0U7, CP17A_CAPHI
Q64410, CP17A_CAVPOP12394, CP17A_CHICKQ9GMC8, CP17A_FELCA
Q95328, CP17A_HORSEP05093, CP17A_HUMANO73853, CP17A_ICTPU
Q2XVA1, CP17A_MACFAQ8HYM9, CP17A_MACMUP70687, CP17A_MESAU
P27786, CP17A_MOUSEP30437, CP17A_ONCMYP70085, CP17A_ORYLA
Q8HYN1, CP17A_PANTRQ8HYN0, CP17A_PAPCYQ9GLD2, CP17A_PAPHU
Q91Z85, CP17A_PERLEP19100, CP17A_PIGO57525, CP17A_RANDY
P11715, CP17A_RATQ29497, CP17A_SHEEPQ92113, CP17A_SQUAC

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