A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.14.14.19
| Accepted Name |
|---|
| Steroid 17-alpha-monooxygenase.
|
| Alternative Name(s) |
|---|
| CYP17. |
| CYP17A1. |
| Cytochrome p450 XVIIA1. |
| Steroid 17-alpha-hydroxylase. |
| Steroid 17-alpha-hydroxylase/17,20 lyase. |
| Reaction catalysed |
|---|
| A C(21)-steroid + [reduced NADPH--hemoprotein reductase] + O(2) <=> a 17-alpha-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H(2)O |
| Cofactor(s) |
|---|
| Heme-thiolate.
|
| Comment(s) |
|---|
- Requires NADPH and EC 1.6.2.4.
- Catalyzes two independent reactions at the same active site - the
17-alpha-hydroxylation of pregnenolone and progesterone, which is
part of glucocorticoid hormones biosynthesis, and the conversion of
the 17-alpha-hydroxylated products via a 17,20-lyase reaction to form
androstenedione and dehydroepiandrosterone, leading to sex hormone
biosynthesis (EC 1.14.14.32).
- The ratio of the 17-alpha-hydroxylase and 17,20-lyase activities is
an important factor in determining the directions of steroid hormone
biosynthesis toward biosynthesis of glucocorticoid or sex hormones.
- Formerly EC 1.14.1.7, EC 1.14.99.9 and EC 1.99.1.9.
|
| Cross-references |
|---|
| PROSITE | PDOC00081 |
| BRENDA | 1.14.14.19 |
| EC2PDB | 1.14.14.19 |
| ExplorEnz | 1.14.14.19 |
| PRIAM enzyme-specific profiles | 1.14.14.19 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.19 |
| IUBMB Enzyme Nomenclature | 1.14.14.19 |
| IntEnz | 1.14.14.19 |
| MEDLINE | Find literature relating to 1.14.14.19 |
| MetaCyc | 1.14.14.19 |
| UniProtKB/Swiss-Prot |
| Q9GMC7, CP17A_BISBI; | P05185, CP17A_BOVIN; | Q9N0U7, CP17A_CAPHI; |
| Q64410, CP17A_CAVPO; | P12394, CP17A_CHICK; | Q9GMC8, CP17A_FELCA; |
| Q95328, CP17A_HORSE; | P05093, CP17A_HUMAN; | O73853, CP17A_ICTPU; |
| Q2XVA1, CP17A_MACFA; | Q8HYM9, CP17A_MACMU; | P70687, CP17A_MESAU; |
| P27786, CP17A_MOUSE; | P30437, CP17A_ONCMY; | P70085, CP17A_ORYLA; |
| Q8HYN1, CP17A_PANTR; | Q8HYN0, CP17A_PAPCY; | Q9GLD2, CP17A_PAPHU; |
| Q91Z85, CP17A_PERLE; | P19100, CP17A_PIG; | O57525, CP17A_RANDY; |
| P11715, CP17A_RAT; | Q29497, CP17A_SHEEP; | Q92113, CP17A_SQUAC; |
|
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UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
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