ENZYME entry: EC 184.108.40.206
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|L-isoleucine + 2 O(2) + 2 [reduced NADPH--hemoprotein reductase] <=> (1E,2S)-2-methylbutanal oxime + 2 [oxidized NADPH--hemoprotein reductase] + CO(2) + 3 H(2)O|
- This enzyme, found in plants, catalyzes two successive
N-hydroxylations of L-isoleucine, the committed step in the
biosynthesis of the cyanogenic glucoside lotaustralin.
- The product of the two hydroxylations, N,N-dihydroxy-L-isoleucine,
is labile and undergoes dehydration followed by decarboxylation,
producing the oxime.
- It is still not known whether the decarboxylation is spontaneous or
catalyzed by the enzyme.
- The enzyme can also accept L-valine, but with a lower activity.
- Cf. EC 220.127.116.11, valine N-monooxygenase.
- Formerly EC 18.104.22.168.
|PRIAM enzyme-specific profiles||22.214.171.124|
|KEGG Ligand Database for Enzyme Nomenclature||126.96.36.199|
|IUBMB Enzyme Nomenclature||188.8.131.52|
|MEDLINE||Find literature relating to 184.108.40.206|
|Rhea expert-curated reactions||220.127.116.11|
entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-