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ENZYME

ENZYME entry: EC 1.14.14.42

PURL: https://purl.expasy.org/enzyme/EC/1.14.14.42
Accepted Name
homomethionine N-monooxygenase
Alternative Name(s)
CYP79F1
Reaction catalysed
an L-polyhomomethionine + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = an (E)-omega-(methylsulfanyl)-alkanal oxime + 2 oxidized [NADPH--hemoprotein reductase] + CO2 + 3 H2O + 2 H(+)
Comment(s)
  • Involved in methionine-derived aliphatic glucosinolates biosynthesis.
  • It catalyzes two successive N-hydroxylations, which are followed by dehydration and decarboxylation.
  • CYP79F1 from Arabidopsis thaliana can metabolize homo-, di-, tri-, tetra-, penta-, and hexahomomethionine to their corresponding aldoximes, while CYP79F2 from the same plant can only metabolize penta- and hexahomomethionine.
  • Formerly EC 1.14.13.n5.
Cross-references
BRENDA1.14.14.42
EC2PDB1.14.14.42
ExplorEnz1.14.14.42
KEGG Ligand Database for Enzyme Nomenclature1.14.14.42
IUBMB Enzyme Nomenclature1.14.14.42
MEDLINEFind literature relating to 1.14.14.42
MetaCyc1.14.14.42
Rhea expert-curated reactions1.14.14.42
UniProtKB/Swiss-Prot
Q949U1, C79F1_ARATHQ9FUY7, C79F2_ARATH

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