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ENZYME entry: EC 1.14.14.42

Accepted Name
Homomethionine N-monooxygenase.
Alternative Name(s)
CYP79F1.
Reaction catalysed
An L-polyhomomethionine + 2 O(2) + 2 [reduced NADPH--hemoprotein reductase] <=> an omega-(methylthio)-(E)-alkanal oxime + CO(2) + 3 H(2)O + 2 [oxidized NADPH--hemoprotein reductase]
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Involved in methionine-derived aliphatic glucosinolates biosynthesis.
  • It catalyzes two successive N-hydroxylations, which are followed by dehydration and decarboxylation.
  • CYP79F1 from Arabidopsis thaliana can metabolize homo-, di-, tri-, tetra-, penta-, and hexahomomethionine to their corresponding aldoximes, while CYP79F2 from the same plant can only metabolize penta- and hexahomomethionine.
  • Formerly EC 1.14.13.n5 and EC 1.14.13.n6.
Cross-references
BRENDA1.14.14.42
EC2PDB1.14.14.42
ExplorEnz1.14.14.42
PRIAM enzyme-specific profiles1.14.14.42
KEGG Ligand Database for Enzyme Nomenclature1.14.14.42
IUBMB Enzyme Nomenclature1.14.14.42
IntEnz1.14.14.42
MEDLINEFind literature relating to 1.14.14.42
MetaCyc1.14.14.42
UniProtKB/Swiss-Prot
Q949U1, C79F1_ARATH;  Q9FUY7, C79F2_ARATH;  

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