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ENZYME entry: EC 1.14.14.47

Accepted Name
Nitric-oxide synthase (flavodoxin).
Alternative Name(s)
Nitric oxide synthetase.
NO synthase.
Reaction catalysed
2 L-arginine + 3 reduced flavodoxin + 4 O(2) <=> 2 L-citrulline + 2 nitric oxide + 3 oxidized flavodoxin + 4 H(2)O
Cofactor(s)
5,6,7,8-tetrahydrobiopterin; Ferriheme b.
Comment(s)
  • The enzyme, found in bacteria and archaea, consist of only an oxygenase domain and functions together with bacterial ferredoxins or flavodoxins.
  • The orthologous enzymes from plants and animals also contain a reductase domain and use only NADPH as the electron donor (cf. EC 1.14.13.39).
  • Formerly EC 1.14.13.165.
Cross-references
BRENDA1.14.14.47
EC2PDB1.14.14.47
ExplorEnz1.14.14.47
PRIAM enzyme-specific profiles1.14.14.47
KEGG Ligand Database for Enzyme Nomenclature1.14.14.47
IUBMB Enzyme Nomenclature1.14.14.47
IntEnz1.14.14.47
MEDLINEFind literature relating to 1.14.14.47
MetaCyc1.14.14.47
UniProtKB/Swiss-Prot
O34453, NOSO_BACSU;  Q9RR97, NOSO_DEIRA;  Q5HEK7, NOSO_STAAC;  
P0A092, NOSO_STAAM;  P0A093, NOSO_STAAN;  Q6GFE2, NOSO_STAAR;  
Q6G818, NOSO_STAAS;  P0A004, NOSO_STAAU;  P0A094, NOSO_STAAW;  

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