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ENZYME

ENZYME entry: EC 1.14.14.47

PURL: https://purl.expasy.org/enzyme/EC/1.14.14.47
Accepted Name
nitric-oxide synthase (flavodoxin)
Alternative Name(s)
nitric oxide synthetase
NO synthase
Reaction catalysed
3 reduced [flavodoxin] + 2 L-arginine + 4 O2 = 3 oxidized [flavodoxin] + 2 L-citrulline + 2 nitric oxide + 4 H2O + 5 H(+)
Comment(s)
  • The enzyme, found in bacteria and archaea, consist of only an oxygenase domain and functions together with bacterial ferredoxins or flavodoxins.
  • The orthologous enzymes from plants and animals also contain a reductase domain and use only NADPH as the electron donor (cf. EC 1.14.13.39).
  • Formerly EC 1.14.13.165.
Cross-references
BRENDA1.14.14.47
EC2PDB1.14.14.47
ExplorEnz1.14.14.47
KEGG Ligand Database for Enzyme Nomenclature1.14.14.47
IUBMB Enzyme Nomenclature1.14.14.47
MEDLINEFind literature relating to 1.14.14.47
MetaCyc1.14.14.47
Rhea expert-curated reactions1.14.14.47
UniProtKB/Swiss-Prot
O34453, NOSO_BACSUQ9RR97, NOSO_DEIRAQ5HEK7, NOSO_STAAC
P0A092, NOSO_STAAMP0A093, NOSO_STAANQ6GFE2, NOSO_STAAR
Q6G818, NOSO_STAASP0A004, NOSO_STAAUP0A094, NOSO_STAAW

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