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ENZYME entry: EC 1.14.14.49

Accepted Name
12-hydroxyjasmonoyl-L-amino acid 12-hydroxylase.
Alternative Name(s)
CYP94C1.
Reaction catalysed
A 12-hydroxyjasmonoyl-L-amino acid + 2 [reduced NADPH--hemoprotein reductase] + 2 O(2) <=> a 12-hydroxy-12-oxojasmonoyl-L-amino acid + 2 [oxidized NADPH--hemoprotein reductase] + 3 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • The enzyme, found in plants, acts on jasmonoyl-L-amino conjugates that have been hydroxylated at the C-12 position of the jasmonic acid chain by EC 1.14.14.48 further oxidizing that position to a carboxylate via an aldehyde intermediate.
  • While the best studied substrate is (+)-7-iso-jasmonoyl-L-isoleucine, the enzyme was shown to be active with jasmonoyl-L-phenylalanine, and is likely to be active with other jasmonoyl-amino acid conjugates.
Cross-references
BRENDA1.14.14.49
EC2PDB1.14.14.49
ExplorEnz1.14.14.49
PRIAM enzyme-specific profiles1.14.14.49
KEGG Ligand Database for Enzyme Nomenclature1.14.14.49
IUBMB Enzyme Nomenclature1.14.14.49
IntEnz1.14.14.49
MEDLINEFind literature relating to 1.14.14.49
MetaCyc1.14.14.49
UniProtKB/Swiss-Prot
Q9ZUX1, C94C1_ARATH

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