ENZYME entry: EC 1.14.14.57
Accepted Name |
Taurochenodeoxycholate 6-alpha-hydroxylase.
|
Alternative Name(s) |
CYP3A4. |
CYP4A21. |
Taurochenodeoxycholate 6-alpha-monooxygenase. |
Reaction catalysed |
- Taurochenodeoxycholate + [reduced NADPH--hemoprotein reductase] + O(2) <=> taurohyocholate + [oxidized NADPH--hemoprotein reductase] + H(2)O
- Lithocholate + [reduced NADPH--hemoprotein reductase] + O(2) <=> hyodeoxycholate + [oxidized NADPH--hemoprotein reductase] + H(2)O
|
Cofactor(s) |
Heme-thiolate.
|
Comment(s) |
- Requires cytochrome b5 for maximal activity.
- Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on
lithocholate and chenodeoxycholate.
- In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a
primary bile acid.
- Formerly EC 1.14.13.97.
|
Cross-references |
PROSITE | PDOC00081 |
BRENDA | 1.14.14.57 |
EC2PDB | 1.14.14.57 |
ExplorEnz | 1.14.14.57 |
PRIAM enzyme-specific profiles | 1.14.14.57 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.57 |
IUBMB Enzyme Nomenclature | 1.14.14.57 |
IntEnz | 1.14.14.57 |
MEDLINE | Find literature relating to 1.14.14.57 |
MetaCyc | 1.14.14.57 |
Rhea expert-curated reactions | 1.14.14.57 |
UniProtKB/Swiss-Prot |
|
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