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ENZYME entry: EC 1.14.14.57

Accepted Name
Taurochenodeoxycholate 6-alpha-hydroxylase.
Alternative Name(s)
CYP3A4.
CYP4A21.
Taurochenodeoxycholate 6-alpha-monooxygenase.
Reaction catalysed
  • Taurochenodeoxycholate + [reduced NADPH--hemoprotein reductase] + O(2) <=> taurohyocholate + [oxidized NADPH--hemoprotein reductase] + H(2)O
  • Lithocholate + [reduced NADPH--hemoprotein reductase] + O(2) <=> hyodeoxycholate + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Requires cytochrome b5 for maximal activity.
  • Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on lithocholate and chenodeoxycholate.
  • In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a primary bile acid.
  • Formerly EC 1.14.13.97.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.57
EC2PDB1.14.14.57
ExplorEnz1.14.14.57
PRIAM enzyme-specific profiles1.14.14.57
KEGG Ligand Database for Enzyme Nomenclature1.14.14.57
IUBMB Enzyme Nomenclature1.14.14.57
IntEnz1.14.14.57
MEDLINEFind literature relating to 1.14.14.57
MetaCyc1.14.14.57
Rhea expert-curated reactions1.14.14.57
UniProtKB/Swiss-Prot
Q9GJX5, CP4AL_PIG

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