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ENZYME

ENZYME entry: EC 1.14.14.78

Accepted Name
phylloquinone omega-hydroxylase
Alternative Name(s)
CYP4F11
CYP4F2
Reaction catalysed
O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein isolated from human tissue.
  • The enzyme will also act on menaquinone-4.
  • Prolonged action of CYP4F2, but not CYP4F11, on the omega hydroxyl group oxidizes it to the corresponding carboxylic acid.
  • CYP4F2 also oxidizes leukotriene B4; see EC 1.14.13.30.
  • Formerly EC 1.14.13.194.
Cross-references
BRENDA1.14.14.78
EC2PDB1.14.14.78
ExplorEnz1.14.14.78
PRIAM enzyme-specific profiles1.14.14.78
KEGG Ligand Database for Enzyme Nomenclature1.14.14.78
IUBMB Enzyme Nomenclature1.14.14.78
IntEnz1.14.14.78
MEDLINEFind literature relating to 1.14.14.78
MetaCyc1.14.14.78
Rhea expert-curated reactions1.14.14.78
UniProtKB/Swiss-Prot
P78329, CP4F2_HUMANQ9HBI6, CP4FB_HUMAN

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