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ENZYME entry: EC 1.14.14.79

Accepted Name
Docosahexaenoic acid omega-hydroxylase.
Alternative Name(s)
CYP4F3B.
CYP4V2.
Reaction catalysed
Docosahexaenoate + [reduced NADPH--hemoprotein reductase] + O(2) <=> 22-hydroxydocosahexaenoate + [oxidized NADPH--hemoprotein reductase] + H(2)O
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein isolated from human eye tissue.
  • Defects in the enzyme are associated with Bietti crystalline corneoretinal dystrophy.
  • The enzyme also produces some 21-hydroxydocosahexaenoate.
  • Acts in a similar way on icosapentaenoic acid.
  • Formerly EC 1.14.13.199.
Cross-references
BRENDA1.14.14.79
EC2PDB1.14.14.79
ExplorEnz1.14.14.79
PRIAM enzyme-specific profiles1.14.14.79
KEGG Ligand Database for Enzyme Nomenclature1.14.14.79
IUBMB Enzyme Nomenclature1.14.14.79
IntEnz1.14.14.79
MEDLINEFind literature relating to 1.14.14.79
MetaCyc1.14.14.79
UniProtKB/Swiss-Prot
P78329, CP4F2_HUMAN;  Q08477, CP4F3_HUMAN;  Q9HBI6, CP4FB_HUMAN;  
Q6ZWL3, CP4V2_HUMAN;  Q9DBW0, CP4V2_MOUSE;  Q5RCN6, CP4V2_PONAB;  
A2RRT9, CP4V2_RAT;  

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