Expasy logo

ENZYME

ENZYME entry: EC 1.14.14.79

PURL: https://purl.expasy.org/enzyme/EC/1.14.14.79
Accepted Name
docosahexaenoic acid omega-hydroxylase
Alternative Name(s)
CYP4F3B
CYP4V2
Reaction catalysed
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein isolated from human eye tissue.
  • Defects in the enzyme are associated with Bietti crystalline corneoretinal dystrophy.
  • The enzyme also produces some 21-hydroxydocosahexaenoate.
  • Acts in a similar way on icosapentaenoic acid.
  • Formerly EC 1.14.13.199.
Cross-references
BRENDA1.14.14.79
EC2PDB1.14.14.79
ExplorEnz1.14.14.79
KEGG Ligand Database for Enzyme Nomenclature1.14.14.79
IUBMB Enzyme Nomenclature1.14.14.79
MEDLINEFind literature relating to 1.14.14.79
MetaCyc1.14.14.79
Rhea expert-curated reactions1.14.14.79
UniProtKB/Swiss-Prot
P78329, CP4F2_HUMANQ08477, CP4F3_HUMANQ9HBI6, CP4FB_HUMAN
Q6ZWL3, CP4V2_HUMANQ9DBW0, CP4V2_MOUSEQ5RCN6, CP4V2_PONAB
A2RRT9, CP4V2_RAT

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-