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ENZYME

ENZYME entry: EC 1.14.14.80

PURL: https://purl.expasy.org/enzyme/EC/1.14.14.80
Accepted Name
long-chain fatty acid omega-monooxygenase
Alternative Name(s)
CYP4A
CYP52M1
CYP704B1
CYP86A
Reaction catalysed
an omega-methyl-long-chain fatty acid + reduced [NADPH--hemoprotein reductase] + O2 = an omega-hydroxy-long-chain fatty acid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Comment(s)
  • A cytochrome P450 (heme thiolate) enzyme.
  • The plant enzyme CYP704B1, which is involved in the synthesis of sporopollenin, a complex polymer found at the outer layer of spores and pollen, acts on palmitate (18:0), stearate (18:0) and oleate (18:1).
  • The plant enzyme CYP86A1 also acts on laurate (12:0).
  • The enzyme from the yeast Starmerella bombicola (CYP52M1) acts on C16 to C20 saturated and unsaturated fatty acids and can also hydroxylate the (omega-1) position.
  • The mammalian enzyme CYP4A acts on laurate (12:0), myristate (14:0), palmitate (16:0), oleate (18:1), and arachidonate (20:4).
  • Formerly EC 1.14.13.205.
Cross-references
BRENDA1.14.14.80
EC2PDB1.14.14.80
ExplorEnz1.14.14.80
KEGG Ligand Database for Enzyme Nomenclature1.14.14.80
IUBMB Enzyme Nomenclature1.14.14.80
MEDLINEFind literature relating to 1.14.14.80
MetaCyc1.14.14.80
Rhea expert-curated reactions1.14.14.80
UniProtKB/Swiss-Prot
Q9C788, C70B1_ARATHP48422, C86A1_ARATHQ0IIF9, CP2U1_BOVIN
Q7Z449, CP2U1_HUMANQ9CX98, CP2U1_MOUSEQ4V8D1, CP2U1_RAT
P20816, CP4A2_RATP14579, CP4A5_RABITP14580, CP4A6_RABIT
P14581, CP4A7_RABITO88833, CP4AA_MOUSEP08516, CP4AA_RAT
Q02928, CP4AB_HUMANP20817, CP4AE_RATQ5TCH4, CP4AM_HUMAN
Q8SPK1, CP4AO_PIGQ8SPK0, CP4AP_PIGQ9HBI6, CP4FB_HUMAN
Q6ZWL3, CP4V2_HUMANQ9DBW0, CP4V2_MOUSEQ5RCN6, CP4V2_PONAB
A2RRT9, CP4V2_RATB8QHP3, CP52E_STABOB8QHP1, CP52M_STABO
B8QHP5, CP52N_STABO

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