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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.14.80

Accepted Name
Long-chain fatty acid omega-monooxygenase.
Alternative Name(s)
CYP4A.
CYP52M1.
CYP704B1.
CYP86A.
Reaction catalysed
A long-chain fatty acid + [reduced NADPH--hemoprotein reductase] + O(2) <=> an omega-hydroxy-long-chain fatty acid + [oxidized NADPH--hemoprotein reductase] + H(2)O
Comment(s)
  • A cytochrome P450 (heme thiolate) enzyme.
  • The plant enzyme CYP704B1, which is involved in the synthesis of sporopollenin, a complex polymer found at the outer layer of spores and pollen, acts on palmitate (18:0), stearate (18:0) and oleate (18:1).
  • The plant enzyme CYP86A1 also acts on laurate (12:0).
  • The enzyme from the yeast Starmerella bombicola (CYP52M1) acts on C(16) to C(20) saturated and unsaturated fatty acids and can also hydroxylate the (omega-1) position.
  • The mammalian enzyme CYP4A acts on laurate (12:0), myristate (14:0), palmitate (16:0), oleate (18:1), and arachidonate (20:4).
  • Formerly EC 1.14.13.205.
Cross-references
BRENDA1.14.14.80
EC2PDB1.14.14.80
ExplorEnz1.14.14.80
PRIAM enzyme-specific profiles1.14.14.80
KEGG Ligand Database for Enzyme Nomenclature1.14.14.80
IUBMB Enzyme Nomenclature1.14.14.80
IntEnz1.14.14.80
MEDLINEFind literature relating to 1.14.14.80
MetaCyc1.14.14.80
UniProtKB/Swiss-Prot
Q9C788, C70B1_ARATH;  P48422, C86A1_ARATH;  P20816, CP4A2_RAT;  
P14579, CP4A5_RABIT;  P14580, CP4A6_RABIT;  P14581, CP4A7_RABIT;  
O88833, CP4AA_MOUSE;  P08516, CP4AA_RAT;  Q02928, CP4AB_HUMAN;  
O35728, CP4AE_MOUSE;  P20817, CP4AE_RAT;  Q5TCH4, CP4AM_HUMAN;  
Q8SPK1, CP4AO_PIG;  Q8SPK0, CP4AP_PIG;  

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