ENZYME entry: EC 1.14.14.81
Accepted Name |
Flavonoid 3',5'-hydroxylase.
|
Alternative Name(s) |
F3',5'H. |
F3'5'H. |
Reaction catalysed |
A flavanone + 2 [reduced NADPH--hemoprotein reductase] + 2 O(2) <=> a 3',5'-dihydroxyflavanone + 2 [oxidized NADPH--hemoprotein reductase] + 2 H(2)O |
Cofactor(s) |
Heme-thiolate.
|
Comment(s) |
- A cytochrome P450 (heme-thiolate) protein found in plants.
- The 3',5'-dihydroxyflavanone is formed via the 3'-hydroxyflavanone.
- In Petunia hybrida the enzyme acts on naringenin, eriodictyol,
dihydroquercetin (taxifolin) and dihydrokaempferol (aromadendrin).
- The enzyme catalyzes the hydroxylation of 5,7,4'-trihydroxyflavanone
(naringenin) at either the 3' position to form eriodictyol or at both
the 3' and 5' positions to form 5,7,3',4',5'-pentahydroxyflavanone
(dihydrotricetin).
- The enzyme also catalyzes the hydroxylation of
3,5,7,3',4'-pentahydroxyflavanone (taxifolin) at the 5' position,
forming ampelopsin.
- Formerly EC 1.14.13.88.
|
Cross-references |
PROSITE | PDOC00081 |
BRENDA | 1.14.14.81 |
EC2PDB | 1.14.14.81 |
ExplorEnz | 1.14.14.81 |
PRIAM enzyme-specific profiles | 1.14.14.81 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.81 |
IUBMB Enzyme Nomenclature | 1.14.14.81 |
IntEnz | 1.14.14.81 |
MEDLINE | Find literature relating to 1.14.14.81 |
MetaCyc | 1.14.14.81 |
Rhea expert-curated reactions | 1.14.14.81 |
UniProtKB/Swiss-Prot |
|
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