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ENZYME

ENZYME entry: EC 1.14.14.81

PURL: https://purl.expasy.org/enzyme/EC/1.14.14.81
Accepted Name
flavonoid 3',5'-hydroxylase
Alternative Name(s)
F3',5'H
F3'5'H
Reaction catalysed
a 3',5'-unsubstituted flavanone + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = a 3',5'-dihydroxyflavanone + 2 oxidized [NADPH--hemoprotein reductase] + 2 H2O + 2 H(+)
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein found in plants.
  • The 3',5'-dihydroxyflavanone is formed via the 3'-hydroxyflavanone.
  • In Petunia hybrida the enzyme acts on naringenin, eriodictyol, dihydroquercetin (taxifolin) and dihydrokaempferol (aromadendrin).
  • The enzyme catalyzes the hydroxylation of 5,7,4'-trihydroxyflavanone (naringenin) at either the 3' position to form eriodictyol or at both the 3' and 5' positions to form 5,7,3',4',5'-pentahydroxyflavanone (dihydrotricetin).
  • The enzyme also catalyzes the hydroxylation of 3,5,7,3',4'-pentahydroxyflavanone (taxifolin) at the 5' position, forming ampelopsin.
  • Formerly EC 1.14.13.88.
Cross-references
BRENDA1.14.14.81
EC2PDB1.14.14.81
ExplorEnz1.14.14.81
KEGG Ligand Database for Enzyme Nomenclature1.14.14.81
IUBMB Enzyme Nomenclature1.14.14.81
MEDLINEFind literature relating to 1.14.14.81
MetaCyc1.14.14.81
Rhea expert-curated reactions1.14.14.81
UniProtKB/Swiss-Prot
P48418, C75A1_PETHYP37120, C75A2_SOLMEP48419, C75A3_PETHY
Q96581, C75A4_GENTRQ96418, C75A5_EUSERO04773, C75A6_CAMME
O04790, C75A7_EUSERA0A4D6Q414, CYP2_CROXC

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