Home  |  Contact

ENZYME entry: EC 1.14.14.89

Accepted Name
4'-methoxyisoflavone 2'-hydroxylase.
Alternative Name(s)
CYP81E1.
CYP81E3.
CYP81E7.
Isoflavone 2'-hydroxylase.
Isoflavone 2'-monooxygenase.
Reaction catalysed
Formononetin + [reduced NADPH--hemoprotein reductase] + O(2) <=> 2'-hydroxyformononetin + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein.
  • Acts on isoflavones with a 4'-methoxy group, such as formononetin and biochanin A.
  • Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.
  • EC 1.14.14.90 is less specific and acts on other isoflavones as well as 4'-methoxyisoflavones.
  • Formerly EC 1.14.13.53.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.89
EC2PDB1.14.14.89
ExplorEnz1.14.14.89
PRIAM enzyme-specific profiles1.14.14.89
KEGG Ligand Database for Enzyme Nomenclature1.14.14.89
IUBMB Enzyme Nomenclature1.14.14.89
IntEnz1.14.14.89
MEDLINEFind literature relating to 1.14.14.89
MetaCyc1.14.14.89
UniProtKB/Swiss-Prot
Q6WNR0, C81E7_MEDTR

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-